Retinol‐binding protein 4 as a plasma biomarker of renal dysfunction and cardiovascular disease in type 2 diabetes

. Objective. The retinol‐binding protein 4 (RBP4) has been linked to the insulin resistance state in obesity and type 2 diabetes in animal studies. Data in humans are controversial and their relationship with organ damage in diabetic patients is lacking. We studied the association of plasma RBP4 wi...

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Veröffentlicht in:	Journal of internal medicine 2007-10, Vol.262 (4), p.496-503
Hauptverfasser:	Cabré, A., Lázaro, I., Girona, J., Manzanares, J., Marimón, F., Plana, N., Heras, M., Masana, L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences Biomarkers - blood cardiovascular disease Cardiovascular Diseases - etiology Cardiovascular Diseases - metabolism Diabetes Mellitus, Type 2 - blood Diabetic Nephropathies - blood Female General aspects Humans Male Medical sciences Middle Aged Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure RBP4 Renal failure renal function Retinol-Binding Proteins - metabolism Retinol-Binding Proteins, Plasma type 2 diabetes
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Zusammenfassung:	. Objective. The retinol‐binding protein 4 (RBP4) has been linked to the insulin resistance state in obesity and type 2 diabetes in animal studies. Data in humans are controversial and their relationship with organ damage in diabetic patients is lacking. We studied the association of plasma RBP4 with organ complications in type 2 diabetic patients. Setting. Sant Joan University Hospital, Reus, Spain. Subjects. 165 nonsmoker type 2 diabetic subjects according to American Diabetes Association criteria, aged 36–79 years, without proteinuria or severely decreased glomerular filtration rates (MDRD‐GFR
ISSN:	0954-6820 1365-2796
DOI:	10.1111/j.1365-2796.2007.01849.x