Transcriptional Activator TonE‐Binding Protein in Cellular Protection and Differentiation

The TonE‐binding protein (TonEBP) is a transcriptional activator in the Rel family that includes NFκB and NFAT. TonEBP is critical for the development and function of the renal medulla, which is a major regulator of water homeostasis. TonEBP is also implicated in diabetic nephropathy and inflammatio...

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Hauptverfasser:	Kim, Jeong Ah, Jeon, Un Sil, Kwon, Min Seong, Lim, Sun Woo, Moo Kwon, H.
Format:	Buchkapitel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Cell Differentiation - physiology Electrophoretic Mobility Shift Assay Humans Hypertonic Solutions - pharmacology Kidney Medulla - physiology Molecular Sequence Data NFATC Transcription Factors - analysis NFATC Transcription Factors - immunology NFATC Transcription Factors - physiology RNA Interference
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Zusammenfassung:	The TonE‐binding protein (TonEBP) is a transcriptional activator in the Rel family that includes NFκB and NFAT. TonEBP is critical for the development and function of the renal medulla, which is a major regulator of water homeostasis. TonEBP is also implicated in diabetic nephropathy and inflammation. Established methods for biochemical and histochemical detection and functional analysis of TonEBP, including identification of novel TonEBP target genes, are described for those who are interested in investigating function and regulation of TonEBP.
ISSN:	0076-6879 1557-7988
DOI:	10.1016/S0076-6879(07)28014-0