Anti-tubercular agents. Part IV: Synthesis and antimycobacterial evaluation of nitroheterocyclic-based 1,2,4-benzothiadiazines

In continuation of our earlier work on benzothiadiazines, we have prepared a series of nitrofuran, nitrothiophene and arylfuran coupled benzothiadiazines and evaluated them for antimycobacterial and antibacterial activities. One of the compounds 2f has shown good in vitro antimycobacterial activity....

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2007-10, Vol.17 (19), p.5419-5422
Hauptverfasser:	Kamal, Ahmed, Kaleem Ahmed, S., Srinivasa Reddy, K., Khan, M. Naseer A., Shetty, Rajesh V.C.R.N.C., Siddhardha, B., Murthy, U.S.N., Khan, Inshad Ali, Kumar, Manoj, Sharma, Sandeep, Ram, Anshu Beulah
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - pharmacology Antibacterial Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antimycobacterial Antitubercular Agents - chemical synthesis Antitubercular Agents - pharmacology Arylfurans Bacteria - drug effects Benzothiadiazines Benzothiadiazines - chemical synthesis Benzothiadiazines - pharmacology Biological and medical sciences Indicators and Reagents Medical sciences Microbial Sensitivity Tests Mycobacterium tuberculosis - drug effects Nitrofuran Nitrothiophene Pharmacology. Drug treatments Structure-Activity Relationship
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Beschreibung
Zusammenfassung:	In continuation of our earlier work on benzothiadiazines, we have prepared a series of nitrofuran, nitrothiophene and arylfuran coupled benzothiadiazines and evaluated them for antimycobacterial and antibacterial activities. One of the compounds 2f has shown good in vitro antimycobacterial activity. All the synthesized compounds have shown moderate to good antibacterial activity.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2007.07.027