Anti-HIV-1 constituents from leaves and twigs of Cratoxylum arborescens

Abstract Two new xanthones, 1,3,8-trihydroxy-2,4-dimethoxyxanthone (1) and 1,7-dihydroxy-2,8-dimethoxyxanthone (2), along with twelve known compounds 3 - 14 were isolated from leaves and twigs of CRATOXYLUM ARBORESCENS. Compound 1, euxanthone (4), betulinic acid (8), lup-20(29)-ene-3β,30-diol (9), 3...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Planta medica 2006-12, Vol.72 (15), p.1433-1435
Hauptverfasser:	Reutrakul, V, Chanakul, W, Jaipetch, T, Yoosook, C, Kasisit, J, Napaswat, C, Santisuk, T, Prabpai, S, Kongsaeree, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-HIV Agents - administration & dosage Anti-HIV Agents - chemistry Anti-HIV Agents - pharmacology Anti-HIV Agents - therapeutic use antiviral properties Biological and medical sciences chemical structure Clusiaceae Cratoxylum arborescens dimethoxyxanthone euxanthone General pharmacology HIV-1 - drug effects Human immunodeficiency virus 1 Humans Letter Medical sciences Microbial Sensitivity Tests Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plant Components, Aerial Plant Extracts - administration & dosage Plant Extracts - chemistry Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Leaves spectral analysis Structure-Activity Relationship xanthones
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Abstract Two new xanthones, 1,3,8-trihydroxy-2,4-dimethoxyxanthone (1) and 1,7-dihydroxy-2,8-dimethoxyxanthone (2), along with twelve known compounds 3 - 14 were isolated from leaves and twigs of CRATOXYLUM ARBORESCENS. Compound 1, euxanthone (4), betulinic acid (8), lup-20(29)-ene-3β,30-diol (9), 3β-hydroxylup-20(29)-en-30-oic acid (10) and 3,4-dihydroxybenzoic acid (11) displayed anti-HIV-1 activities in the syncytium assay using Δ Tat/Rev MC99 virus and the 1A2 cell line system (EC 50 values between 3.9 and 32.2 μg/mL with TI ranging from 1.5 to 11.7), while 1,3,7-trihydroxy-6-methoxy-4,5-diisoprenylxanthone (3), 4, and 8 - 10 inhibited HIV-1 reverse transcriptase with IC 50 values between 8.7 and 84.9 μg/mL.
ISSN:	0032-0943 1439-0221
DOI:	10.1055/s-2006-951725