Targeted Agents: The Rules of Combination

The success of molecularly targeted agents (MTA) in the treatment of cancer has led to the investigation of their use in combination with other MTAs and with conventional chemotherapies. An overview of the MTAs that have emerged as Food and Drug Administration–approved drugs is presented, along with...

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Veröffentlicht in:	Clinical cancer research 2007-09, Vol.13 (18), p.5232-5237
Hauptverfasser:	KWAK, Eunice L, CLARK, Jeffrey W, CHABNER, Bruce
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Antineoplastic Combined Chemotherapy Protocols - pharmacology Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences combination therapy Drug Approval Drug Resistance, Neoplasm Humans Medical sciences molecularly targeted agents Neoplasms - drug therapy Neoplasms - metabolism Pharmacology. Drug treatments United States United States Food and Drug Administration
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Beschreibung
Zusammenfassung:	The success of molecularly targeted agents (MTA) in the treatment of cancer has led to the investigation of their use in combination with other MTAs and with conventional chemotherapies. An overview of the MTAs that have emerged as Food and Drug Administration–approved drugs is presented, along with a framework for the consideration of how MTAs can best be combined to maximize therapeutic effect.
ISSN:	1078-0432 1557-3265
DOI:	10.1158/1078-0432.CCR-07-1385