Lymph Node Metastases Displaying Lower Ki-67 Immunostaining Activity than the Primary Breast Cancer

Lymph Node Metastases Displaying Lower Ki-67 Immunostaining Activity than the Primary Breast Cancer

The aim of the study was to verify by Ki-67 immunostaining if any difference exists in the cell proliferating fraction between primary breast tumors (PTs) and matching positive axillary lymph nodes (ALNs). Patients and Methods: Immunohistochemistry with the monoclonal antibody against Ki-67 was perf...

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Veröffentlicht in:Anticancer research 2006-11, Vol.26 (6B), p.4357-4360
Hauptverfasser: CABIBI, D, MUSTACCHIO, V, MARTORANA, A, TRIPODO, C, CAMPIONE, M, CALASCIBETTA, A, SANGUEDOLCE, R, ARAGONA, F
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Breast Neoplasms - immunology
Female
Hematologic and hematopoietic diseases
Humans
Ki-67 Antigen - immunology
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphatic Metastasis - immunology
Medical sciences
Tumors
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Zusammenfassung:The aim of the study was to verify by Ki-67 immunostaining if any difference exists in the cell proliferating fraction between primary breast tumors (PTs) and matching positive axillary lymph nodes (ALNs). Patients and Methods: Immunohistochemistry with the monoclonal antibody against Ki-67 was performed in 160 node-positive breast carcinomas and in their respective lymph node metastases. Results: An increase of Ki-67 immunoreactive cells in ALN compared with that of PTs was observed in 84% of cases (ALN: mean 17%, PTs: mean 8%; p
ISSN:0250-7005
1791-7530