Gastrointestinal stromal tumors: Differential diagnosis

Availability of KIT tyrosine kinase inhibitors for specific treatment of GISTs has magnified the importance of accurate differential diagnosis of GIST from other tumors occurring in the GI tract and abdomen. The general problems in this distinction include histological mimicry of other mesenchymal t...

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Veröffentlicht in:	Seminars in diagnostic pathology 2006-05, Vol.23 (2), p.111-119
Hauptverfasser:	Dow, Nancy, Giblen, Georgeta, Sobin, Leslie H., Miettinen, Markku
Format:	Artikel
Sprache:	eng
Schlagworte:	Desmoid Diagnosis, Differential Differential diagnosis Gastrointestinal Stromal Tumors - diagnosis Gastrointestinal Stromal Tumors - pathology GIST Humans Immunohistochemistry Inflammatory myofibroblastic tumor Melanoma Neoplasms, Connective and Soft Tissue - diagnosis PDGFRA Proto-Oncogene Proteins c-kit - metabolism Sarcoma
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Beschreibung
Zusammenfassung:	Availability of KIT tyrosine kinase inhibitors for specific treatment of GISTs has magnified the importance of accurate differential diagnosis of GIST from other tumors occurring in the GI tract and abdomen. The general problems in this distinction include histological mimicry of other mesenchymal tumors with GIST, occasional KIT-negativity of GIST, and KIT-positivity of non-GISTs. Up to 5% to 10% gastric GISTs and
ISSN:	0740-2570 1930-1111
DOI:	10.1053/j.semdp.2006.09.002