Controlled Ligand Display on a Symmetrical Protein-Cage Architecture Through Mixed Assembly

Controlled Ligand Display on a Symmetrical Protein-Cage Architecture Through Mixed Assembly

Do you feel caged in? The surface of protein‐cage structures can effectively be covered with a controlled density of different ligands (see picture). In vitro reassembly of independently modified cage subunits mixed at varying molar ratios generates particles with a defined mean number of a function...

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Veröffentlicht in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2006-08, Vol.2 (8-9), p.962-966
Hauptverfasser: Gillitzer, Eric, Suci, Peter, Young, Mark, Douglas, Trevor
Format: Artikel
Sprache:eng
Schlagworte:
Bromovirus - chemistry
Bromovirus - metabolism
Capsid Proteins - chemistry
Capsid Proteins - metabolism
host-guest interactions
icosahedral architecture
Ligands
Protein Binding - physiology
protein cages
self-assembly
viruses
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Beschreibung
Zusammenfassung:Do you feel caged in? The surface of protein‐cage structures can effectively be covered with a controlled density of different ligands (see picture). In vitro reassembly of independently modified cage subunits mixed at varying molar ratios generates particles with a defined mean number of a functional ligand attached to the surface of the protein cage.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.200500433