En Route to an Efficient Catalytic Asymmetric Synthesis of AS-3201

A catalytic asymmetric synthesis of AS-3201 via catalytic asymmetric amination with a novel lanthanum−amide complex is described. The amination reaction proceeded efficiently with as little as 1 mol % of catalyst loading, allowing for an efficient access to the key intermediate for the synthesis of...

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Veröffentlicht in:	Journal of the American Chemical Society 2007-09, Vol.129 (37), p.11342-11343
Hauptverfasser:	Mashiko, Tomoyuki, Hara, Keiichi, Tanaka, Daisuke, Fujiwara, Yuji, Kumagai, Naoya, Shibasaki, Masakatsu
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehyde Reductase - antagonists & inhibitors Amination Catalysis Hypoglycemic Agents - chemical synthesis Hypoglycemic Agents - chemistry Hypoglycemic Agents - pharmacology Molecular Structure Pyrazines - chemical synthesis Pyrazines - chemistry Pyrazines - pharmacology Spiro Compounds - chemical synthesis Spiro Compounds - chemistry Spiro Compounds - pharmacology
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Beschreibung
Zusammenfassung:	A catalytic asymmetric synthesis of AS-3201 via catalytic asymmetric amination with a novel lanthanum−amide complex is described. The amination reaction proceeded efficiently with as little as 1 mol % of catalyst loading, allowing for an efficient access to the key intermediate for the synthesis of AS-3201, a potent aldose reductase inhibitor.
ISSN:	0002-7863 1520-5126
DOI:	10.1021/ja0752585