One- and Two-Photon Excited Optical pH Probing for Cells Using Surface-Enhanced Raman and Hyper-Raman Nanosensors
We demonstrate spatially resolved probing and imaging of pH in live cells by mobile and biocompatible nanosensors using surface-enhanced Raman scattering (SERS) of 4-mercaptobenzoic acid (pMBA) on gold nanoaggregates. Moreover, we also show that this concept of pH nanosensors can be extended to two-...
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| Veröffentlicht in: | Nano letters 2007-09, Vol.7 (9), p.2819-2823 |
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| container_end_page | 2823 |
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| container_issue | 9 |
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| container_title | Nano letters |
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| creator | Kneipp, Janina Kneipp, Harald Wittig, Burghardt Kneipp, Katrin |
| description | We demonstrate spatially resolved probing and imaging of pH in live cells by mobile and biocompatible nanosensors using surface-enhanced Raman scattering (SERS) of 4-mercaptobenzoic acid (pMBA) on gold nanoaggregates. Moreover, we also show that this concept of pH nanosensors can be extended to two-photon excitation by using surface-enhanced hyper-Raman scattering (SEHRS). In addition to the advantages of two-photon excitation, the SEHRS sensor enables measurements over a wide pH range without the use of multiple probes. |
| doi_str_mv | 10.1021/nl071418z |
| format | Article |
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Moreover, we also show that this concept of pH nanosensors can be extended to two-photon excitation by using surface-enhanced hyper-Raman scattering (SEHRS). 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Moreover, we also show that this concept of pH nanosensors can be extended to two-photon excitation by using surface-enhanced hyper-Raman scattering (SEHRS). 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Kneipp, Harald ; Wittig, Burghardt ; Kneipp, Katrin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a440t-f9325e7823508ecabbf31271745a26cc8fce8245c260d45a2aa12651440a6c6e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Biosensing Techniques - instrumentation</topic><topic>Biosensing Techniques - methods</topic><topic>Condensed matter: structure, mechanical and thermal properties</topic><topic>Equipment Design</topic><topic>Equipment Failure Analysis</topic><topic>Exact sciences and technology</topic><topic>General equipment and techniques</topic><topic>Hydrogen-Ion Concentration</topic><topic>Instruments, apparatus, components and techniques common to several branches of physics and astronomy</topic><topic>Low-dimensional structures (superlattices, quantum well structures, multilayers): structure, and nonelectronic properties</topic><topic>Mice</topic><topic>Microscopy, Fluorescence, Multiphoton - instrumentation</topic><topic>Microscopy, Fluorescence, Multiphoton - methods</topic><topic>Nanotechnology - instrumentation</topic><topic>Nanotechnology - methods</topic><topic>NIH 3T3 Cells</topic><topic>Physics</topic><topic>Sensors (chemical, optical, electrical, movement, gas, etc.); 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| ispartof | Nano letters, 2007-09, Vol.7 (9), p.2819-2823 |
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| source | MEDLINE; ACS Publications |
| subjects | Animals Biosensing Techniques - instrumentation Biosensing Techniques - methods Condensed matter: structure, mechanical and thermal properties Equipment Design Equipment Failure Analysis Exact sciences and technology General equipment and techniques Hydrogen-Ion Concentration Instruments, apparatus, components and techniques common to several branches of physics and astronomy Low-dimensional structures (superlattices, quantum well structures, multilayers): structure, and nonelectronic properties Mice Microscopy, Fluorescence, Multiphoton - instrumentation Microscopy, Fluorescence, Multiphoton - methods Nanotechnology - instrumentation Nanotechnology - methods NIH 3T3 Cells Physics Sensors (chemical, optical, electrical, movement, gas, etc.) remote sensing Spectrum Analysis, Raman - instrumentation Spectrum Analysis, Raman - methods Surfaces and interfaces thin films and whiskers (structure and nonelectronic properties) |
| title | One- and Two-Photon Excited Optical pH Probing for Cells Using Surface-Enhanced Raman and Hyper-Raman Nanosensors |
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