Effect of complex phytoadaptogen on MPTP-induced Parkinson's syndrome in mice

Oral administration of 10% solution of Phytomix-40 (multicomponent plant phytoadaptogen) to C57Bl/6 mice with MPTP-induced Parkinson's syndrome alleviated symptoms (oligokinesia and muscle rigidity), compensated for the deficiency of dopamine and its metabolites (DOPAC and homovanillic acid), a...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2006-05, Vol.141 (5), p.560-563
Hauptverfasser:	Bocharov, E V, Kucheryanu, V G, Kryzhanovskii, G N, Bocharova, O A, Kudrin, V S, Belorustseva, S A
Format:	Artikel
Sprache:	eng
Schlagworte:	3,4-Dihydroxyphenylacetic Acid - metabolism Animals Chromatography, High Pressure Liquid Corpus Striatum - metabolism Dopamine - metabolism Homovanillic Acid - metabolism Lipid Peroxides - metabolism Mice Mice, Inbred C57BL Motor Activity - drug effects Muscle Rigidity - drug therapy Muscle Rigidity - pathology Parkinsonian Disorders - drug therapy Parkinsonian Disorders - pathology Plant Extracts - pharmacology Plant Extracts - therapeutic use Serotonin - metabolism
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Zusammenfassung:	Oral administration of 10% solution of Phytomix-40 (multicomponent plant phytoadaptogen) to C57Bl/6 mice with MPTP-induced Parkinson's syndrome alleviated symptoms (oligokinesia and muscle rigidity), compensated for the deficiency of dopamine and its metabolites (DOPAC and homovanillic acid), and reduced the level of lipid peroxides in the striatum. In vitro Phytomix-40 in a concentration of 3.3 x 10(-2) g/liter exhibited a pronounced antioxidant effect (5-fold decreased MDA level in mouse brain homogenate in Fe(2+)-ascorbate-dependent LPO).
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-006-0220-2