Pharmacokinetics of Cycloalliin, an Organosulfur Compound Found in Garlic and Onion, in Rats
Cycloalliin, an organosulfur compound found in garlic and onion, has been reported to exert several biological activities and also to remain stable during storage and processing. In this study, we investigated the pharmacokinetics of cycloalliin in rats after intravenous or oral administration. Cycl...
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Veröffentlicht in: | Journal of agricultural and food chemistry 2006-12, Vol.54 (26), p.9811-9819 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Cycloalliin, an organosulfur compound found in garlic and onion, has been reported to exert several biological activities and also to remain stable during storage and processing. In this study, we investigated the pharmacokinetics of cycloalliin in rats after intravenous or oral administration. Cycloalliin and its metabolite, (3R,5S)-5-methyl-1,4-thiazane-3-carboxylic acid, in plasma, urine, feces, and organs was determined by a validated liquid chromatography−mass spectrometry method. When administered intravenously at 50 mg/kg, cycloalliin was rapidly eliminated from blood and excreted into urine, and its total recovery in urine was 97.8% ± 1.3% in 48 h. After oral administration, cycloalliin appeared rapidly in plasma, with a t max of 0.47 ± 0.03 h at 25 mg/kg and 0.67 ± 0.14 h at 50 mg/kg. Orally administered cycloalliin was distributed in heart, lung, liver, spleen, and especially kidney. The C max and AUC 0-inf values of cycloalliin at 50 mg/kg were approximately 5 times those at 25 mg/kg. When administered orally at 50 mg/kg, cycloalliin was excreted into urine (17.6% ± 4.2%) but not feces. However, the total fecal excretion of (3R,5S)-5-methyl-1,4-thiazane-3-carboxylic acid was 67.3% ± 5.9% (value corrected for cycloalliin equivalents). In addition, no (3R,5S)-5-methyl-1,4-thiazane-3-carboxylic acid was detected in plasma ( |
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ISSN: | 0021-8561 1520-5118 |
DOI: | 10.1021/jf062252a |