The Lymphopenic Mouse in Immunology: From Patron to Pariah

A recent surge of interest in the behavior of T and B cells in lymphopenic model systems has resurrected a certain cynicism about the validity of using such models to answer important immunological questions. Here we discuss this skepticism in a broader historical context.

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Veröffentlicht in:Immunity (Cambridge, Mass.) Mass.), 2006-12, Vol.25 (6), p.851-855
Hauptverfasser: Singh, Nevil J., Schwartz, Ronald H.
Format: Artikel
Sprache:eng
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Zusammenfassung:A recent surge of interest in the behavior of T and B cells in lymphopenic model systems has resurrected a certain cynicism about the validity of using such models to answer important immunological questions. Here we discuss this skepticism in a broader historical context.
ISSN:1074-7613
1097-4180
DOI:10.1016/j.immuni.2006.12.002