Highly Enantioselective Recognition of Dicarboxylic Acid Substrates by the Control of Nonlinear Responses

An allosteric host, in which the molecular information of the chiral guest was precisely introduced, exhibits unconventional enantioselectivity toward the target enantiomer even under the conditions of a −20% enantiomeric excess (ee) mixture within a certain concentration window. This is effected by incorporation of the structural information of the enantiomer into the host and the utilization of multiple equilibrium.