A Soluble Form of Lymphocyte Activation Gene-3 (IMP321) Induces Activation of a Large Range of Human Effector Cytotoxic Cells

The principal antitumor immune response is mediated through the activation of type 1 cytotoxic (Tc1) CD8 T cells, NK cells, and monocytes/macrophages. In this study, we investigated the potency of a clinical-grade soluble form of lymphocyte activation gene-3 protein (IMP321), a physiological high-af...

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Veröffentlicht in:	Journal of Immunology 2007-09, Vol.179 (6), p.4202-4211
Hauptverfasser:	Brignone, Chrystelle, Grygar, Caroline, Marcu, Manon, Schakel, Knut, Triebel, Frederic
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD - genetics Antigens, CD - metabolism Antigens, CD - physiology CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell Proliferation Chemokines - biosynthesis Cytokines - biosynthesis Dendritic Cells - immunology Dendritic Cells - metabolism Humans Immunity, Active Immunity, Innate Immunologic Memory Interleukin-10 - metabolism Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - metabolism Lymphocyte Activation - immunology Myeloid Cells - immunology Myeloid Cells - metabolism Protein Binding - immunology Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Recombinant Fusion Proteins - physiology Solubility T-Lymphocytes, Cytotoxic - classification T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Cytotoxic - metabolism Toll-Like Receptors - agonists
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Zusammenfassung:	The principal antitumor immune response is mediated through the activation of type 1 cytotoxic (Tc1) CD8 T cells, NK cells, and monocytes/macrophages. In this study, we investigated the potency of a clinical-grade soluble form of lymphocyte activation gene-3 protein (IMP321), a physiological high-affinity MHC class II binder, at inducing in PBMCs an appropriate cytotoxic-type response in short-term ex vivo assays. We found that IMP321 binds to a minority (
ISSN:	0022-1767 1550-6606 1365-2567
DOI:	10.4049/jimmunol.179.6.4202