Diversity in Guanine-Selective DNA Binding Modes for an Organometallic Ruthenium Arene Complex

Diversity in Guanine-Selective DNA Binding Modes for an Organometallic Ruthenium Arene Complex

Seek and hide! An organometallic ruthenium arene anticancer complex with ruthenium (pink ball) chelated by ethylenediamine (blue) is selective for guanine bases on DNA and can bury the noncoordinated phenyl ring of its arene ligand (yellow) between bases in the double helix.

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Veröffentlicht in:Angewandte Chemie International Edition 2006-12, Vol.45 (48), p.8153-8156
Hauptverfasser: Liu, Hong-Ke, Berners-Price, Susan J., Wang, Fuyi, Parkinson, John A., Xu, Jingjing, Bella, Juraj, Sadler, Peter J.
Format: Artikel
Sprache:eng
Schlagworte:
anticancer agents
bioinorganic chemistry
DNA
DNA - chemistry
Guanine - chemistry
Models, Molecular
Molecular Structure
NMR spectroscopy
Organometallic Compounds - chemistry
ruthenium
Ruthenium - chemistry
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Zusammenfassung:Seek and hide! An organometallic ruthenium arene anticancer complex with ruthenium (pink ball) chelated by ethylenediamine (blue) is selective for guanine bases on DNA and can bury the noncoordinated phenyl ring of its arene ligand (yellow) between bases in the double helix.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200602873