Location, location, timing: Analysis of cytomegalovirus epitopes for neutralizing antibodies
Abstract Attempts to produce a vaccine to human cytomegalovirus (HCMV) have failed. The principal target of the humoral immune response to HCMV is the viral envelope glycoprotein gB, which contains several immunodominant epitopes. Here we discuss human antibodies reacting with gB and offer an explan...
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| Veröffentlicht in: | Immunology Letters 2007-09, Vol.112 (1), p.58-60 |
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| container_title | Immunology Letters |
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| creator | Schrader, John W McLean, Gary R |
| description | Abstract Attempts to produce a vaccine to human cytomegalovirus (HCMV) have failed. The principal target of the humoral immune response to HCMV is the viral envelope glycoprotein gB, which contains several immunodominant epitopes. Here we discuss human antibodies reacting with gB and offer an explanation as to why most humans make antibodies to an epitope that does not always elicit neutralizing antibodies. We suggest modifications to gB for an improved HCMV vaccine design. |
| doi_str_mv | 10.1016/j.imlet.2007.07.001 |
| format | Article |
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The principal target of the humoral immune response to HCMV is the viral envelope glycoprotein gB, which contains several immunodominant epitopes. Here we discuss human antibodies reacting with gB and offer an explanation as to why most humans make antibodies to an epitope that does not always elicit neutralizing antibodies. We suggest modifications to gB for an improved HCMV vaccine design.</description><identifier>ISSN: 0165-2478</identifier><identifier>EISSN: 1879-0542</identifier><identifier>EISSN: 1365-2567</identifier><identifier>DOI: 10.1016/j.imlet.2007.07.001</identifier><identifier>PMID: 17714794</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Allergy and Immunology ; Antibodies, Viral ; Antibody Formation ; Cytomegalovirus - immunology ; Cytomegalovirus Infections - immunology ; Cytomegalovirus Infections - prevention & control ; Cytomegalovirus Vaccines ; Epitope ; Epitope Mapping ; Human cytomegalovirus ; Humans ; Immunodominant Epitopes ; Neutralization Tests ; Neutralizing antibodies ; Protein Conformation ; Time Factors ; Vaccine ; Viral Envelope Proteins - chemistry ; Viral Envelope Proteins - immunology</subject><ispartof>Immunology Letters, 2007-09, Vol.112 (1), p.58-60</ispartof><rights>Elsevier B.V.</rights><rights>2007 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c358t-73c8353e6159a615059f58cb68b279efe80f1bfa288b618b9a1e42bc4f6449243</citedby><cites>FETCH-LOGICAL-c358t-73c8353e6159a615059f58cb68b279efe80f1bfa288b618b9a1e42bc4f6449243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0165247807001484$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17714794$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schrader, John W</creatorcontrib><creatorcontrib>McLean, Gary R</creatorcontrib><title>Location, location, timing: Analysis of cytomegalovirus epitopes for neutralizing antibodies</title><title>Immunology Letters</title><addtitle>Immunol Lett</addtitle><description>Abstract Attempts to produce a vaccine to human cytomegalovirus (HCMV) have failed. The principal target of the humoral immune response to HCMV is the viral envelope glycoprotein gB, which contains several immunodominant epitopes. Here we discuss human antibodies reacting with gB and offer an explanation as to why most humans make antibodies to an epitope that does not always elicit neutralizing antibodies. We suggest modifications to gB for an improved HCMV vaccine design.</description><subject>Allergy and Immunology</subject><subject>Antibodies, Viral</subject><subject>Antibody Formation</subject><subject>Cytomegalovirus - immunology</subject><subject>Cytomegalovirus Infections - immunology</subject><subject>Cytomegalovirus Infections - prevention & control</subject><subject>Cytomegalovirus Vaccines</subject><subject>Epitope</subject><subject>Epitope Mapping</subject><subject>Human cytomegalovirus</subject><subject>Humans</subject><subject>Immunodominant Epitopes</subject><subject>Neutralization Tests</subject><subject>Neutralizing antibodies</subject><subject>Protein Conformation</subject><subject>Time Factors</subject><subject>Vaccine</subject><subject>Viral Envelope Proteins - chemistry</subject><subject>Viral Envelope Proteins - immunology</subject><issn>0165-2478</issn><issn>1879-0542</issn><issn>1365-2567</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkl1rFDEUhoNY7Fr9BYLMlVfONp-TjGChFL9goRfVOyFksicla2ayJpnC-uvNuIuCN4VDkovnOSHvCUKvCF4TTLrL3dqPAcqaYizXS2HyBK2Ikn2LBadP0apSoqVcqnP0POddBQTj7Bk6J1ISLnu-Qt830Zri4_S2CX9PxY9-un_XXE8mHLLPTXSNPZQ4wr0J8cGnOTew9yXuITcupmaCuSQT_K-qNWYqfohbD_kFOnMmZHh52i_Qt48fvt58bje3n77cXG9ay4QqrWRWMcGgI6I3dcGid0LZoVMDlT04UNiRwRmq1NARNfSGAKeD5a7jvKecXaA3x777FH_OkIsefbYQgpkgzll3itKeC_ooSCRVVDFVQXYEbYo5J3B6n_xo0kETrJf09U7_SV8v6eulMKnW61P7eRhh-885xV2B90cAahoPHpLO1sNkYesT2KK30T9ywdV_vg1-8taEH3CAvItzqiOr79CZaqzvlg-wzB_LanPF2W99bKyI</recordid><startdate>20070915</startdate><enddate>20070915</enddate><creator>Schrader, John W</creator><creator>McLean, Gary R</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20070915</creationdate><title>Location, location, timing: Analysis of cytomegalovirus epitopes for neutralizing antibodies</title><author>Schrader, John W ; McLean, Gary R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c358t-73c8353e6159a615059f58cb68b279efe80f1bfa288b618b9a1e42bc4f6449243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Allergy and Immunology</topic><topic>Antibodies, Viral</topic><topic>Antibody Formation</topic><topic>Cytomegalovirus - immunology</topic><topic>Cytomegalovirus Infections - immunology</topic><topic>Cytomegalovirus Infections - prevention & control</topic><topic>Cytomegalovirus Vaccines</topic><topic>Epitope</topic><topic>Epitope Mapping</topic><topic>Human cytomegalovirus</topic><topic>Humans</topic><topic>Immunodominant Epitopes</topic><topic>Neutralization Tests</topic><topic>Neutralizing antibodies</topic><topic>Protein Conformation</topic><topic>Time Factors</topic><topic>Vaccine</topic><topic>Viral Envelope Proteins - chemistry</topic><topic>Viral Envelope Proteins - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schrader, John W</creatorcontrib><creatorcontrib>McLean, Gary R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Immunology Letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schrader, John W</au><au>McLean, Gary R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Location, location, timing: Analysis of cytomegalovirus epitopes for neutralizing antibodies</atitle><jtitle>Immunology Letters</jtitle><addtitle>Immunol Lett</addtitle><date>2007-09-15</date><risdate>2007</risdate><volume>112</volume><issue>1</issue><spage>58</spage><epage>60</epage><pages>58-60</pages><issn>0165-2478</issn><eissn>1879-0542</eissn><eissn>1365-2567</eissn><abstract>Abstract Attempts to produce a vaccine to human cytomegalovirus (HCMV) have failed. The principal target of the humoral immune response to HCMV is the viral envelope glycoprotein gB, which contains several immunodominant epitopes. Here we discuss human antibodies reacting with gB and offer an explanation as to why most humans make antibodies to an epitope that does not always elicit neutralizing antibodies. We suggest modifications to gB for an improved HCMV vaccine design.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>17714794</pmid><doi>10.1016/j.imlet.2007.07.001</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0165-2478 |
| ispartof | Immunology Letters, 2007-09, Vol.112 (1), p.58-60 |
| issn | 0165-2478 1879-0542 1365-2567 |
| language | eng |
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| source | MEDLINE; IngentaConnect Free/Open Access Journals; Wiley Online Library Journals Frontfile Complete; Elsevier ScienceDirect Journals; Wiley Online Library Free Content; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Allergy and Immunology Antibodies, Viral Antibody Formation Cytomegalovirus - immunology Cytomegalovirus Infections - immunology Cytomegalovirus Infections - prevention & control Cytomegalovirus Vaccines Epitope Epitope Mapping Human cytomegalovirus Humans Immunodominant Epitopes Neutralization Tests Neutralizing antibodies Protein Conformation Time Factors Vaccine Viral Envelope Proteins - chemistry Viral Envelope Proteins - immunology |
| title | Location, location, timing: Analysis of cytomegalovirus epitopes for neutralizing antibodies |
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