Location, location, timing: Analysis of cytomegalovirus epitopes for neutralizing antibodies

Abstract Attempts to produce a vaccine to human cytomegalovirus (HCMV) have failed. The principal target of the humoral immune response to HCMV is the viral envelope glycoprotein gB, which contains several immunodominant epitopes. Here we discuss human antibodies reacting with gB and offer an explan...

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Veröffentlicht in:	Immunology Letters 2007-09, Vol.112 (1), p.58-60
Hauptverfasser:	Schrader, John W, McLean, Gary R
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Antibodies, Viral Antibody Formation Cytomegalovirus - immunology Cytomegalovirus Infections - immunology Cytomegalovirus Infections - prevention & control Cytomegalovirus Vaccines Epitope Epitope Mapping Human cytomegalovirus Humans Immunodominant Epitopes Neutralization Tests Neutralizing antibodies Protein Conformation Time Factors Vaccine Viral Envelope Proteins - chemistry Viral Envelope Proteins - immunology
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Beschreibung
Zusammenfassung:	Abstract Attempts to produce a vaccine to human cytomegalovirus (HCMV) have failed. The principal target of the humoral immune response to HCMV is the viral envelope glycoprotein gB, which contains several immunodominant epitopes. Here we discuss human antibodies reacting with gB and offer an explanation as to why most humans make antibodies to an epitope that does not always elicit neutralizing antibodies. We suggest modifications to gB for an improved HCMV vaccine design.
ISSN:	0165-2478 1879-0542 1365-2567
DOI:	10.1016/j.imlet.2007.07.001