Quantification of Left Ventricular Volumes and Function in Patients with Cardiomyopathies by Real-time Three-dimensional Echocardiography: A Head-to-Head Comparison Between Two Different Semiautomated Endocardial Border Detection Algorithms
Objective We evaluated two different commercially available real-time 3-dimensional echocardiographic semiautomated border detection algorithms for left ventricular (LV) volume analysis in patients with cardiomyopathy and distorted LV geometry. Methods A total of 53 patients in sinus rhythm with var...
Gespeichert in:
| Veröffentlicht in: | Journal of the American Society of Echocardiography 2007-09, Vol.20 (9), p.1042-1049 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1049 |
|---|---|
| container_issue | 9 |
| container_start_page | 1042 |
| container_title | Journal of the American Society of Echocardiography |
| container_volume | 20 |
| creator | Soliman, Osama I.I., MD Krenning, Boudewijn J., MD Geleijnse, Marcel L., MD, PhD Nemes, Attila, MD, PhD Bosch, Johan G., PhD van Geuns, Robert-Jan, MD, PhD Kirschbaum, Sharon W., MD Anwar, Ashraf M., MD Galema, Tjebbe W., MD Vletter, Wim B., MSc ten Cate, Folkert J., MD, PhD |
| description | Objective We evaluated two different commercially available real-time 3-dimensional echocardiographic semiautomated border detection algorithms for left ventricular (LV) volume analysis in patients with cardiomyopathy and distorted LV geometry. Methods A total of 53 patients in sinus rhythm with various types of cardiomyopathy (mean age 56 ± 11 years, 28 men) and adequate 2-dimensional image quality were included. The real-time 3-dimensional echocardiographic multiplane interpolation (MI) and full volume reconstruction (FVR) methods were used for LV volume analysis. Magnetic resonance imaging was used as the reference method. Results A strong correlation ( R2 > 0.95) was found for all LV volume and ejection fraction measurements by either real-time 3-dimensional echocardiographic method. Analysis time was shorter with the FVR method (6 ± 2 vs 15 ± 4 minutes, P < .01) as compared with the MI method. Bland-Altman analysis showed greater underestimation of end-diastolic and end-systolic volumes by MI compared with FVR. For the MI method a bias of −24.0 mL (−15.0% of the mean) for end-diastolic volume and −11.3 mL (−18.0% of the mean) for end-systolic volume was found. For FVR analysis these values were −9.9 mL (−6.0% of the mean) and −5.0 mL (−9.0% of the mean), respectively. Ejection fraction was similar for the MI and FVR method with a mean difference compared with magnetic resonance imaging of 0.6 (1.0%) and 0.8 (1.3%), respectively. Conclusion In patients with cardiomyopathy, distorted LV geometry, and good 2-dimensional image quality, the FVR method is faster and more accurate than the MI method in assessment of LV volumes. |
| doi_str_mv | 10.1016/j.echo.2007.02.011 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68229048</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0894731707001526</els_id><sourcerecordid>68229048</sourcerecordid><originalsourceid>FETCH-LOGICAL-c409t-aec35818ccbfc90942d4d8a14971e500cdf83afeeaedb0a10f4131489a9710173</originalsourceid><addsrcrecordid>eNp9kk1vEzEQhlcIREPhD3BAPnHbdLzfixBSmqYUKRIfDb1ajj1uHHbt1PYS5V_3J-BtIiFx4DQ-PO87M34nSd5SmFKg1cV2imJjpxlAPYVsCpQ-SyYU2jqt6rZ8nkygaYu0zml9lrzyfgsAZQPwMjmjdVlVVVtNksfvAzdBKy140NYQq8gSVSB3aILTYui4I3e2G3r0hBtJrgcjnkBtyLcoiZgnex02ZM6d1LY_2B0PGx3x9YH8QN6lQfdIVhuHmMr4ND7KeUcWcXbxpLl3fLc5fCAzcoNcpsGmYyVz2--40z42u8SwRzRktbfkSiuFLvYlt9hrPgTb84CSLIw8-kXvS-skOnKFAY_Tzrp76-KUvX-dvFC88_jmVM-Tn9eL1fwmXX79_GU-W6aigDakHEVeNrQRYq1EC22RyUI2nBZtTbEEEFI1OVeIHOUaOAVV0JwWTcsjALTOz5P3R9-dsw8D-sB67QV2HTdoB8-qJstaKJoIZkdQOOu9Q8V2TvfcHRgFNubMtmzMmY05M8hYzDmK3p3ch3WP8q_kFGwEPh4BjDv-1uiYFzEsgVK7-CdMWv1__0__yEWnTTyS7hce0G_t4GKGnlHmo4Ddjpc2HhrUALTMqvwPZJDVAw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68229048</pqid></control><display><type>article</type><title>Quantification of Left Ventricular Volumes and Function in Patients with Cardiomyopathies by Real-time Three-dimensional Echocardiography: A Head-to-Head Comparison Between Two Different Semiautomated Endocardial Border Detection Algorithms</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Soliman, Osama I.I., MD ; Krenning, Boudewijn J., MD ; Geleijnse, Marcel L., MD, PhD ; Nemes, Attila, MD, PhD ; Bosch, Johan G., PhD ; van Geuns, Robert-Jan, MD, PhD ; Kirschbaum, Sharon W., MD ; Anwar, Ashraf M., MD ; Galema, Tjebbe W., MD ; Vletter, Wim B., MSc ; ten Cate, Folkert J., MD, PhD</creator><creatorcontrib>Soliman, Osama I.I., MD ; Krenning, Boudewijn J., MD ; Geleijnse, Marcel L., MD, PhD ; Nemes, Attila, MD, PhD ; Bosch, Johan G., PhD ; van Geuns, Robert-Jan, MD, PhD ; Kirschbaum, Sharon W., MD ; Anwar, Ashraf M., MD ; Galema, Tjebbe W., MD ; Vletter, Wim B., MSc ; ten Cate, Folkert J., MD, PhD</creatorcontrib><description>Objective We evaluated two different commercially available real-time 3-dimensional echocardiographic semiautomated border detection algorithms for left ventricular (LV) volume analysis in patients with cardiomyopathy and distorted LV geometry. Methods A total of 53 patients in sinus rhythm with various types of cardiomyopathy (mean age 56 ± 11 years, 28 men) and adequate 2-dimensional image quality were included. The real-time 3-dimensional echocardiographic multiplane interpolation (MI) and full volume reconstruction (FVR) methods were used for LV volume analysis. Magnetic resonance imaging was used as the reference method. Results A strong correlation ( R2 > 0.95) was found for all LV volume and ejection fraction measurements by either real-time 3-dimensional echocardiographic method. Analysis time was shorter with the FVR method (6 ± 2 vs 15 ± 4 minutes, P < .01) as compared with the MI method. Bland-Altman analysis showed greater underestimation of end-diastolic and end-systolic volumes by MI compared with FVR. For the MI method a bias of −24.0 mL (−15.0% of the mean) for end-diastolic volume and −11.3 mL (−18.0% of the mean) for end-systolic volume was found. For FVR analysis these values were −9.9 mL (−6.0% of the mean) and −5.0 mL (−9.0% of the mean), respectively. Ejection fraction was similar for the MI and FVR method with a mean difference compared with magnetic resonance imaging of 0.6 (1.0%) and 0.8 (1.3%), respectively. Conclusion In patients with cardiomyopathy, distorted LV geometry, and good 2-dimensional image quality, the FVR method is faster and more accurate than the MI method in assessment of LV volumes.</description><identifier>ISSN: 0894-7317</identifier><identifier>EISSN: 1097-6795</identifier><identifier>DOI: 10.1016/j.echo.2007.02.011</identifier><identifier>PMID: 17566696</identifier><language>eng</language><publisher>United States: Mosby, Inc</publisher><subject>Algorithms ; Cardiomyopathies - diagnostic imaging ; Cardiomyopathies - physiopathology ; Cardiovascular ; Echocardiography, Three-Dimensional - methods ; Female ; Humans ; Image Processing, Computer-Assisted ; Linear Models ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Sensitivity and Specificity ; Transducers ; Ventricular Dysfunction, Left - diagnostic imaging ; Ventricular Dysfunction, Left - physiopathology</subject><ispartof>Journal of the American Society of Echocardiography, 2007-09, Vol.20 (9), p.1042-1049</ispartof><rights>American Society of Echocardiography</rights><rights>2007 American Society of Echocardiography</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-aec35818ccbfc90942d4d8a14971e500cdf83afeeaedb0a10f4131489a9710173</citedby><cites>FETCH-LOGICAL-c409t-aec35818ccbfc90942d4d8a14971e500cdf83afeeaedb0a10f4131489a9710173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0894731707001526$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17566696$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Soliman, Osama I.I., MD</creatorcontrib><creatorcontrib>Krenning, Boudewijn J., MD</creatorcontrib><creatorcontrib>Geleijnse, Marcel L., MD, PhD</creatorcontrib><creatorcontrib>Nemes, Attila, MD, PhD</creatorcontrib><creatorcontrib>Bosch, Johan G., PhD</creatorcontrib><creatorcontrib>van Geuns, Robert-Jan, MD, PhD</creatorcontrib><creatorcontrib>Kirschbaum, Sharon W., MD</creatorcontrib><creatorcontrib>Anwar, Ashraf M., MD</creatorcontrib><creatorcontrib>Galema, Tjebbe W., MD</creatorcontrib><creatorcontrib>Vletter, Wim B., MSc</creatorcontrib><creatorcontrib>ten Cate, Folkert J., MD, PhD</creatorcontrib><title>Quantification of Left Ventricular Volumes and Function in Patients with Cardiomyopathies by Real-time Three-dimensional Echocardiography: A Head-to-Head Comparison Between Two Different Semiautomated Endocardial Border Detection Algorithms</title><title>Journal of the American Society of Echocardiography</title><addtitle>J Am Soc Echocardiogr</addtitle><description>Objective We evaluated two different commercially available real-time 3-dimensional echocardiographic semiautomated border detection algorithms for left ventricular (LV) volume analysis in patients with cardiomyopathy and distorted LV geometry. Methods A total of 53 patients in sinus rhythm with various types of cardiomyopathy (mean age 56 ± 11 years, 28 men) and adequate 2-dimensional image quality were included. The real-time 3-dimensional echocardiographic multiplane interpolation (MI) and full volume reconstruction (FVR) methods were used for LV volume analysis. Magnetic resonance imaging was used as the reference method. Results A strong correlation ( R2 > 0.95) was found for all LV volume and ejection fraction measurements by either real-time 3-dimensional echocardiographic method. Analysis time was shorter with the FVR method (6 ± 2 vs 15 ± 4 minutes, P < .01) as compared with the MI method. Bland-Altman analysis showed greater underestimation of end-diastolic and end-systolic volumes by MI compared with FVR. For the MI method a bias of −24.0 mL (−15.0% of the mean) for end-diastolic volume and −11.3 mL (−18.0% of the mean) for end-systolic volume was found. For FVR analysis these values were −9.9 mL (−6.0% of the mean) and −5.0 mL (−9.0% of the mean), respectively. Ejection fraction was similar for the MI and FVR method with a mean difference compared with magnetic resonance imaging of 0.6 (1.0%) and 0.8 (1.3%), respectively. Conclusion In patients with cardiomyopathy, distorted LV geometry, and good 2-dimensional image quality, the FVR method is faster and more accurate than the MI method in assessment of LV volumes.</description><subject>Algorithms</subject><subject>Cardiomyopathies - diagnostic imaging</subject><subject>Cardiomyopathies - physiopathology</subject><subject>Cardiovascular</subject><subject>Echocardiography, Three-Dimensional - methods</subject><subject>Female</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Linear Models</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Sensitivity and Specificity</subject><subject>Transducers</subject><subject>Ventricular Dysfunction, Left - diagnostic imaging</subject><subject>Ventricular Dysfunction, Left - physiopathology</subject><issn>0894-7317</issn><issn>1097-6795</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kk1vEzEQhlcIREPhD3BAPnHbdLzfixBSmqYUKRIfDb1ajj1uHHbt1PYS5V_3J-BtIiFx4DQ-PO87M34nSd5SmFKg1cV2imJjpxlAPYVsCpQ-SyYU2jqt6rZ8nkygaYu0zml9lrzyfgsAZQPwMjmjdVlVVVtNksfvAzdBKy140NYQq8gSVSB3aILTYui4I3e2G3r0hBtJrgcjnkBtyLcoiZgnex02ZM6d1LY_2B0PGx3x9YH8QN6lQfdIVhuHmMr4ND7KeUcWcXbxpLl3fLc5fCAzcoNcpsGmYyVz2--40z42u8SwRzRktbfkSiuFLvYlt9hrPgTb84CSLIw8-kXvS-skOnKFAY_Tzrp76-KUvX-dvFC88_jmVM-Tn9eL1fwmXX79_GU-W6aigDakHEVeNrQRYq1EC22RyUI2nBZtTbEEEFI1OVeIHOUaOAVV0JwWTcsjALTOz5P3R9-dsw8D-sB67QV2HTdoB8-qJstaKJoIZkdQOOu9Q8V2TvfcHRgFNubMtmzMmY05M8hYzDmK3p3ch3WP8q_kFGwEPh4BjDv-1uiYFzEsgVK7-CdMWv1__0__yEWnTTyS7hce0G_t4GKGnlHmo4Ddjpc2HhrUALTMqvwPZJDVAw</recordid><startdate>20070901</startdate><enddate>20070901</enddate><creator>Soliman, Osama I.I., MD</creator><creator>Krenning, Boudewijn J., MD</creator><creator>Geleijnse, Marcel L., MD, PhD</creator><creator>Nemes, Attila, MD, PhD</creator><creator>Bosch, Johan G., PhD</creator><creator>van Geuns, Robert-Jan, MD, PhD</creator><creator>Kirschbaum, Sharon W., MD</creator><creator>Anwar, Ashraf M., MD</creator><creator>Galema, Tjebbe W., MD</creator><creator>Vletter, Wim B., MSc</creator><creator>ten Cate, Folkert J., MD, PhD</creator><general>Mosby, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070901</creationdate><title>Quantification of Left Ventricular Volumes and Function in Patients with Cardiomyopathies by Real-time Three-dimensional Echocardiography: A Head-to-Head Comparison Between Two Different Semiautomated Endocardial Border Detection Algorithms</title><author>Soliman, Osama I.I., MD ; Krenning, Boudewijn J., MD ; Geleijnse, Marcel L., MD, PhD ; Nemes, Attila, MD, PhD ; Bosch, Johan G., PhD ; van Geuns, Robert-Jan, MD, PhD ; Kirschbaum, Sharon W., MD ; Anwar, Ashraf M., MD ; Galema, Tjebbe W., MD ; Vletter, Wim B., MSc ; ten Cate, Folkert J., MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-aec35818ccbfc90942d4d8a14971e500cdf83afeeaedb0a10f4131489a9710173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Algorithms</topic><topic>Cardiomyopathies - diagnostic imaging</topic><topic>Cardiomyopathies - physiopathology</topic><topic>Cardiovascular</topic><topic>Echocardiography, Three-Dimensional - methods</topic><topic>Female</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Linear Models</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Sensitivity and Specificity</topic><topic>Transducers</topic><topic>Ventricular Dysfunction, Left - diagnostic imaging</topic><topic>Ventricular Dysfunction, Left - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Soliman, Osama I.I., MD</creatorcontrib><creatorcontrib>Krenning, Boudewijn J., MD</creatorcontrib><creatorcontrib>Geleijnse, Marcel L., MD, PhD</creatorcontrib><creatorcontrib>Nemes, Attila, MD, PhD</creatorcontrib><creatorcontrib>Bosch, Johan G., PhD</creatorcontrib><creatorcontrib>van Geuns, Robert-Jan, MD, PhD</creatorcontrib><creatorcontrib>Kirschbaum, Sharon W., MD</creatorcontrib><creatorcontrib>Anwar, Ashraf M., MD</creatorcontrib><creatorcontrib>Galema, Tjebbe W., MD</creatorcontrib><creatorcontrib>Vletter, Wim B., MSc</creatorcontrib><creatorcontrib>ten Cate, Folkert J., MD, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Society of Echocardiography</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Soliman, Osama I.I., MD</au><au>Krenning, Boudewijn J., MD</au><au>Geleijnse, Marcel L., MD, PhD</au><au>Nemes, Attila, MD, PhD</au><au>Bosch, Johan G., PhD</au><au>van Geuns, Robert-Jan, MD, PhD</au><au>Kirschbaum, Sharon W., MD</au><au>Anwar, Ashraf M., MD</au><au>Galema, Tjebbe W., MD</au><au>Vletter, Wim B., MSc</au><au>ten Cate, Folkert J., MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantification of Left Ventricular Volumes and Function in Patients with Cardiomyopathies by Real-time Three-dimensional Echocardiography: A Head-to-Head Comparison Between Two Different Semiautomated Endocardial Border Detection Algorithms</atitle><jtitle>Journal of the American Society of Echocardiography</jtitle><addtitle>J Am Soc Echocardiogr</addtitle><date>2007-09-01</date><risdate>2007</risdate><volume>20</volume><issue>9</issue><spage>1042</spage><epage>1049</epage><pages>1042-1049</pages><issn>0894-7317</issn><eissn>1097-6795</eissn><abstract>Objective We evaluated two different commercially available real-time 3-dimensional echocardiographic semiautomated border detection algorithms for left ventricular (LV) volume analysis in patients with cardiomyopathy and distorted LV geometry. Methods A total of 53 patients in sinus rhythm with various types of cardiomyopathy (mean age 56 ± 11 years, 28 men) and adequate 2-dimensional image quality were included. The real-time 3-dimensional echocardiographic multiplane interpolation (MI) and full volume reconstruction (FVR) methods were used for LV volume analysis. Magnetic resonance imaging was used as the reference method. Results A strong correlation ( R2 > 0.95) was found for all LV volume and ejection fraction measurements by either real-time 3-dimensional echocardiographic method. Analysis time was shorter with the FVR method (6 ± 2 vs 15 ± 4 minutes, P < .01) as compared with the MI method. Bland-Altman analysis showed greater underestimation of end-diastolic and end-systolic volumes by MI compared with FVR. For the MI method a bias of −24.0 mL (−15.0% of the mean) for end-diastolic volume and −11.3 mL (−18.0% of the mean) for end-systolic volume was found. For FVR analysis these values were −9.9 mL (−6.0% of the mean) and −5.0 mL (−9.0% of the mean), respectively. Ejection fraction was similar for the MI and FVR method with a mean difference compared with magnetic resonance imaging of 0.6 (1.0%) and 0.8 (1.3%), respectively. Conclusion In patients with cardiomyopathy, distorted LV geometry, and good 2-dimensional image quality, the FVR method is faster and more accurate than the MI method in assessment of LV volumes.</abstract><cop>United States</cop><pub>Mosby, Inc</pub><pmid>17566696</pmid><doi>10.1016/j.echo.2007.02.011</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0894-7317 |
| ispartof | Journal of the American Society of Echocardiography, 2007-09, Vol.20 (9), p.1042-1049 |
| issn | 0894-7317 1097-6795 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68229048 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Algorithms Cardiomyopathies - diagnostic imaging Cardiomyopathies - physiopathology Cardiovascular Echocardiography, Three-Dimensional - methods Female Humans Image Processing, Computer-Assisted Linear Models Magnetic Resonance Imaging Male Middle Aged Sensitivity and Specificity Transducers Ventricular Dysfunction, Left - diagnostic imaging Ventricular Dysfunction, Left - physiopathology |
| title | Quantification of Left Ventricular Volumes and Function in Patients with Cardiomyopathies by Real-time Three-dimensional Echocardiography: A Head-to-Head Comparison Between Two Different Semiautomated Endocardial Border Detection Algorithms |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-18T23%3A11%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Quantification%20of%20Left%20Ventricular%20Volumes%20and%20Function%20in%20Patients%20with%20Cardiomyopathies%20by%20Real-time%20Three-dimensional%20Echocardiography:%20A%20Head-to-Head%20Comparison%20Between%20Two%20Different%20Semiautomated%20Endocardial%20Border%20Detection%20Algorithms&rft.jtitle=Journal%20of%20the%20American%20Society%20of%20Echocardiography&rft.au=Soliman,%20Osama%20I.I.,%20MD&rft.date=2007-09-01&rft.volume=20&rft.issue=9&rft.spage=1042&rft.epage=1049&rft.pages=1042-1049&rft.issn=0894-7317&rft.eissn=1097-6795&rft_id=info:doi/10.1016/j.echo.2007.02.011&rft_dat=%3Cproquest_cross%3E68229048%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68229048&rft_id=info:pmid/17566696&rft_els_id=S0894731707001526&rfr_iscdi=true |