Complex genetic control of susceptibility to Mycobacterium bovis (Bacille Calmette-Guérin) infection in wild-derived Mus spretus mice
Susceptibility to Mycobacterium bovis Bacille Calmette-Guérin (BCG) is genetically controlled by Nramp1 ( Slc11a1 ). Inbred mouse strains harbor either the resistance ( Nramp1 G169 ) or the susceptibility ( Nramp1 D169 ) allele at Nramp1 . Mus spretus ( Nramp1 G169 ; SPRET/EiJ) is shown to display a...
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| Veröffentlicht in: | Genes and immunity 2006-12, Vol.7 (8), p.684-687 |
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| creator | Turcotte, K Loredo-Osti, J C Fortin, P Schurr, E Morgan, K Gros, P |
| description | Susceptibility to
Mycobacterium bovis
Bacille Calmette-Guérin (BCG) is genetically controlled by
Nramp1
(
Slc11a1
). Inbred mouse strains harbor either the resistance (
Nramp1
G169
) or the susceptibility (
Nramp1
D169
) allele at
Nramp1
.
Mus spretus
(
Nramp1
G169
; SPRET/EiJ) is shown to display an intermediate level of BCG replication in the spleen (log
10
colony-forming units (CFU)∼5), compared to resistant A/J (log
10
CFU∼4.0) and susceptible C57BL/6J (log
10
CFU∼6.0) mice. The presence of genetic modifiers of
Nramp1
-dependent susceptibility to
M. bovis
(BCG) infection in
Mus spretus
was analyzed by whole-genome scanning in 175 mice of an informative (C57BL/6J × SPRET/EiJ) × C57BL/6J backcross.
Nramp1
showed a major effect (
D1Mcg4
,
P |
| doi_str_mv | 10.1038/sj.gene.6364346 |
| format | Article |
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Mycobacterium bovis
Bacille Calmette-Guérin (BCG) is genetically controlled by
Nramp1
(
Slc11a1
). Inbred mouse strains harbor either the resistance (
Nramp1
G169
) or the susceptibility (
Nramp1
D169
) allele at
Nramp1
.
Mus spretus
(
Nramp1
G169
; SPRET/EiJ) is shown to display an intermediate level of BCG replication in the spleen (log
10
colony-forming units (CFU)∼5), compared to resistant A/J (log
10
CFU∼4.0) and susceptible C57BL/6J (log
10
CFU∼6.0) mice. The presence of genetic modifiers of
Nramp1
-dependent susceptibility to
M. bovis
(BCG) infection in
Mus spretus
was analyzed by whole-genome scanning in 175 mice of an informative (C57BL/6J × SPRET/EiJ) × C57BL/6J backcross.
Nramp1
showed a major effect (
D1Mcg4
,
P
<1e
−4
), but additional single marker effects were identified on chromosomes 4 (
D4Mit150
) and × (
DXMit249
) in male mice, and on chromosome 9 (
D9Mit77
) and 17 (
D17Mit81
) in female mice. A strong interaction between
Nramp1
and the major histocompatibility locus was also noted in female mice. The mapped loci may act as modifiers of Nramp1 action, and constitute novel entry points for the parallel search of loci regulating susceptibility to mycobacterial infections in humans.</description><identifier>ISSN: 1466-4879</identifier><identifier>EISSN: 1476-5470</identifier><identifier>DOI: 10.1038/sj.gene.6364346</identifier><identifier>PMID: 17024129</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Cation Transport Proteins - genetics ; Chromosome 9 ; Crosses, Genetic ; Diagnosis ; Gene Expression ; Genetic control ; Genetic Markers - genetics ; Genetic Predisposition to Disease ; Genomes ; Genomics ; Health aspects ; Histocompatibility ; Human Genetics ; Immunology ; Inbreeding ; Mice ; Microsatellite Repeats - genetics ; Models, Genetic ; Mus spretus ; Mycobacterium bovis ; Risk factors ; Rodents ; short-communication ; Spleen ; Spleen - microbiology ; Stem Cells ; Susceptibility ; Tuberculosis ; Tuberculosis - genetics</subject><ispartof>Genes and immunity, 2006-12, Vol.7 (8), p.684-687</ispartof><rights>Springer Nature Limited 2006</rights><rights>COPYRIGHT 2006 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Dec 2006</rights><rights>Nature Publishing Group 2006.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c564t-9975d263cc9e0aad6d30a7c1475652bbf21ba9fa805dccf65eabfacbb84ad2e93</citedby><cites>FETCH-LOGICAL-c564t-9975d263cc9e0aad6d30a7c1475652bbf21ba9fa805dccf65eabfacbb84ad2e93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.gene.6364346$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.gene.6364346$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17024129$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Turcotte, K</creatorcontrib><creatorcontrib>Loredo-Osti, J C</creatorcontrib><creatorcontrib>Fortin, P</creatorcontrib><creatorcontrib>Schurr, E</creatorcontrib><creatorcontrib>Morgan, K</creatorcontrib><creatorcontrib>Gros, P</creatorcontrib><title>Complex genetic control of susceptibility to Mycobacterium bovis (Bacille Calmette-Guérin) infection in wild-derived Mus spretus mice</title><title>Genes and immunity</title><addtitle>Genes Immun</addtitle><addtitle>Genes Immun</addtitle><description>Susceptibility to
Mycobacterium bovis
Bacille Calmette-Guérin (BCG) is genetically controlled by
Nramp1
(
Slc11a1
). Inbred mouse strains harbor either the resistance (
Nramp1
G169
) or the susceptibility (
Nramp1
D169
) allele at
Nramp1
.
Mus spretus
(
Nramp1
G169
; SPRET/EiJ) is shown to display an intermediate level of BCG replication in the spleen (log
10
colony-forming units (CFU)∼5), compared to resistant A/J (log
10
CFU∼4.0) and susceptible C57BL/6J (log
10
CFU∼6.0) mice. The presence of genetic modifiers of
Nramp1
-dependent susceptibility to
M. bovis
(BCG) infection in
Mus spretus
was analyzed by whole-genome scanning in 175 mice of an informative (C57BL/6J × SPRET/EiJ) × C57BL/6J backcross.
Nramp1
showed a major effect (
D1Mcg4
,
P
<1e
−4
), but additional single marker effects were identified on chromosomes 4 (
D4Mit150
) and × (
DXMit249
) in male mice, and on chromosome 9 (
D9Mit77
) and 17 (
D17Mit81
) in female mice. A strong interaction between
Nramp1
and the major histocompatibility locus was also noted in female mice. The mapped loci may act as modifiers of Nramp1 action, and constitute novel entry points for the parallel search of loci regulating susceptibility to mycobacterial infections in humans.</description><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Cation Transport Proteins - genetics</subject><subject>Chromosome 9</subject><subject>Crosses, Genetic</subject><subject>Diagnosis</subject><subject>Gene Expression</subject><subject>Genetic control</subject><subject>Genetic Markers - genetics</subject><subject>Genetic Predisposition to Disease</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Health aspects</subject><subject>Histocompatibility</subject><subject>Human Genetics</subject><subject>Immunology</subject><subject>Inbreeding</subject><subject>Mice</subject><subject>Microsatellite Repeats - genetics</subject><subject>Models, Genetic</subject><subject>Mus spretus</subject><subject>Mycobacterium bovis</subject><subject>Risk factors</subject><subject>Rodents</subject><subject>short-communication</subject><subject>Spleen</subject><subject>Spleen - microbiology</subject><subject>Stem Cells</subject><subject>Susceptibility</subject><subject>Tuberculosis</subject><subject>Tuberculosis - genetics</subject><issn>1466-4879</issn><issn>1476-5470</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFks1q3DAUhU1padK06-6KaKAkC08k2ZatZTq0SSCh0J-1kKXrQYNsuZKcZl6g79Ln6ItVZgaGKQ1FiyvEd484954se03wguCiuQjrxQoGWLCClUXJnmTHpKxZXpU1fjrfGcvLpuZH2YsQ1hgTRhh_nh2RGtOSUH6c_Vy6frTwgGaZaBRSbojeWeQ6FKagYIymNdbEDYoO3W2Ua6WK4M3Uo9bdm4DO3ktlrAW0lLaHGCG_mn7_8mY4R2boQEXjhnRDP4zVuU6d96DR3RRQGD3EVHuj4GX2rJM2wKtdPcm-ffzwdXmd3366ulle3uaqYmXMOa8rTVmhFAcspWa6wLJWyXPFKtq2HSWt5J1scKWV6lgFsu2katumlJoCL06yd1vd0bvvE4QoepNMWisHcFMQrKE0TbL6L0hxTauaFAk8_Qtcu8kPyYRISqSmDWtm6u2jFGk4prwge6mVtCDS8Fz0Us3_ikvSUE5x2dBELf5BpaMhTdIN0Jn0ftBwftAwbxge4kpOIYibL58P2Ystq7wLwUMnRm966TeCYDEnToS1mKMidolLHW92zqa2B73ndxFLAN4Cad9mWIHfW39M8w_LVuMZ</recordid><startdate>20061201</startdate><enddate>20061201</enddate><creator>Turcotte, K</creator><creator>Loredo-Osti, J C</creator><creator>Fortin, P</creator><creator>Schurr, E</creator><creator>Morgan, K</creator><creator>Gros, P</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20061201</creationdate><title>Complex genetic control of susceptibility to Mycobacterium bovis (Bacille Calmette-Guérin) infection in wild-derived Mus spretus mice</title><author>Turcotte, K ; Loredo-Osti, J C ; Fortin, P ; Schurr, E ; Morgan, K ; Gros, P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c564t-9975d263cc9e0aad6d30a7c1475652bbf21ba9fa805dccf65eabfacbb84ad2e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Cation Transport Proteins - genetics</topic><topic>Chromosome 9</topic><topic>Crosses, Genetic</topic><topic>Diagnosis</topic><topic>Gene Expression</topic><topic>Genetic control</topic><topic>Genetic Markers - genetics</topic><topic>Genetic Predisposition to Disease</topic><topic>Genomes</topic><topic>Genomics</topic><topic>Health aspects</topic><topic>Histocompatibility</topic><topic>Human Genetics</topic><topic>Immunology</topic><topic>Inbreeding</topic><topic>Mice</topic><topic>Microsatellite Repeats - genetics</topic><topic>Models, Genetic</topic><topic>Mus spretus</topic><topic>Mycobacterium bovis</topic><topic>Risk factors</topic><topic>Rodents</topic><topic>short-communication</topic><topic>Spleen</topic><topic>Spleen - microbiology</topic><topic>Stem Cells</topic><topic>Susceptibility</topic><topic>Tuberculosis</topic><topic>Tuberculosis - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Turcotte, K</creatorcontrib><creatorcontrib>Loredo-Osti, J C</creatorcontrib><creatorcontrib>Fortin, P</creatorcontrib><creatorcontrib>Schurr, E</creatorcontrib><creatorcontrib>Morgan, K</creatorcontrib><creatorcontrib>Gros, P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Genes and immunity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Turcotte, K</au><au>Loredo-Osti, J C</au><au>Fortin, P</au><au>Schurr, E</au><au>Morgan, K</au><au>Gros, P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Complex genetic control of susceptibility to Mycobacterium bovis (Bacille Calmette-Guérin) infection in wild-derived Mus spretus mice</atitle><jtitle>Genes and immunity</jtitle><stitle>Genes Immun</stitle><addtitle>Genes Immun</addtitle><date>2006-12-01</date><risdate>2006</risdate><volume>7</volume><issue>8</issue><spage>684</spage><epage>687</epage><pages>684-687</pages><issn>1466-4879</issn><eissn>1476-5470</eissn><abstract>Susceptibility to
Mycobacterium bovis
Bacille Calmette-Guérin (BCG) is genetically controlled by
Nramp1
(
Slc11a1
). Inbred mouse strains harbor either the resistance (
Nramp1
G169
) or the susceptibility (
Nramp1
D169
) allele at
Nramp1
.
Mus spretus
(
Nramp1
G169
; SPRET/EiJ) is shown to display an intermediate level of BCG replication in the spleen (log
10
colony-forming units (CFU)∼5), compared to resistant A/J (log
10
CFU∼4.0) and susceptible C57BL/6J (log
10
CFU∼6.0) mice. The presence of genetic modifiers of
Nramp1
-dependent susceptibility to
M. bovis
(BCG) infection in
Mus spretus
was analyzed by whole-genome scanning in 175 mice of an informative (C57BL/6J × SPRET/EiJ) × C57BL/6J backcross.
Nramp1
showed a major effect (
D1Mcg4
,
P
<1e
−4
), but additional single marker effects were identified on chromosomes 4 (
D4Mit150
) and × (
DXMit249
) in male mice, and on chromosome 9 (
D9Mit77
) and 17 (
D17Mit81
) in female mice. A strong interaction between
Nramp1
and the major histocompatibility locus was also noted in female mice. The mapped loci may act as modifiers of Nramp1 action, and constitute novel entry points for the parallel search of loci regulating susceptibility to mycobacterial infections in humans.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>17024129</pmid><doi>10.1038/sj.gene.6364346</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1466-4879 |
| ispartof | Genes and immunity, 2006-12, Vol.7 (8), p.684-687 |
| issn | 1466-4879 1476-5470 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68226435 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; SpringerLink Journals - AutoHoldings |
| subjects | Animals Biomedical and Life Sciences Biomedicine Cancer Research Cation Transport Proteins - genetics Chromosome 9 Crosses, Genetic Diagnosis Gene Expression Genetic control Genetic Markers - genetics Genetic Predisposition to Disease Genomes Genomics Health aspects Histocompatibility Human Genetics Immunology Inbreeding Mice Microsatellite Repeats - genetics Models, Genetic Mus spretus Mycobacterium bovis Risk factors Rodents short-communication Spleen Spleen - microbiology Stem Cells Susceptibility Tuberculosis Tuberculosis - genetics |
| title | Complex genetic control of susceptibility to Mycobacterium bovis (Bacille Calmette-Guérin) infection in wild-derived Mus spretus mice |
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