Complex genetic control of susceptibility to Mycobacterium bovis (Bacille Calmette-Guérin) infection in wild-derived Mus spretus mice

Complex genetic control of susceptibility to Mycobacterium bovis (Bacille Calmette-Guérin) infection in wild-derived Mus spretus mice

Susceptibility to Mycobacterium bovis Bacille Calmette-Guérin (BCG) is genetically controlled by Nramp1 ( Slc11a1 ). Inbred mouse strains harbor either the resistance ( Nramp1 G169 ) or the susceptibility ( Nramp1 D169 ) allele at Nramp1 . Mus spretus ( Nramp1 G169 ; SPRET/EiJ) is shown to display a...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Genes and immunity 2006-12, Vol.7 (8), p.684-687
Hauptverfasser: Turcotte, K, Loredo-Osti, J C, Fortin, P, Schurr, E, Morgan, K, Gros, P
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biomedical and Life Sciences
Biomedicine
Cancer Research
Cation Transport Proteins - genetics
Chromosome 9
Crosses, Genetic
Diagnosis
Gene Expression
Genetic control
Genetic Markers - genetics
Genetic Predisposition to Disease
Genomes
Genomics
Health aspects
Histocompatibility
Human Genetics
Immunology
Inbreeding
Mice
Microsatellite Repeats - genetics
Models, Genetic
Mus spretus
Mycobacterium bovis
Risk factors
Rodents
short-communication
Spleen
Spleen - microbiology
Stem Cells
Susceptibility
Tuberculosis
Tuberculosis - genetics
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Susceptibility to Mycobacterium bovis Bacille Calmette-Guérin (BCG) is genetically controlled by Nramp1 ( Slc11a1 ). Inbred mouse strains harbor either the resistance ( Nramp1 G169 ) or the susceptibility ( Nramp1 D169 ) allele at Nramp1 . Mus spretus ( Nramp1 G169 ; SPRET/EiJ) is shown to display an intermediate level of BCG replication in the spleen (log 10 colony-forming units (CFU)∼5), compared to resistant A/J (log 10 CFU∼4.0) and susceptible C57BL/6J (log 10 CFU∼6.0) mice. The presence of genetic modifiers of Nramp1 -dependent susceptibility to M. bovis (BCG) infection in Mus spretus was analyzed by whole-genome scanning in 175 mice of an informative (C57BL/6J × SPRET/EiJ) × C57BL/6J backcross. Nramp1 showed a major effect ( D1Mcg4 , P
ISSN:1466-4879
1476-5470
DOI:10.1038/sj.gene.6364346