A strategy of using enoxaparin as adjunctive antithrombin therapy reduces death and recurrent myocardial infarction in patients who achieve early ST-segment resolution after fibrinolytic therapy: the ExTRACT-TIMI 25 ECG study

A strategy of using enoxaparin as adjunctive antithrombin therapy reduces death and recurrent myocardial infarction in patients who achieve early ST-segment resolution after fibrinolytic therapy: the ExTRACT-TIMI 25 ECG study

Aims To determine the relationship between a strategy of enoxaparin (ENOX), early ST-segment resolution (STRes), and clinical outcomes on patients with ST-segment elevation myocardial infarction (STEMI) after fibrinolysis. Methods and results Baseline and 180 min ECGs were analysed in 3208 of the 20...

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Veröffentlicht in:European heart journal 2007-09, Vol.28 (17), p.2070-2076
Hauptverfasser: Scirica, Benjamin M., Morrow, David A., Sadowski, Zygmunt, Ruda, Mikhail, Nicolau, José Carlos, Giugliano, Robert P., Wiviott, Stephen D., Sabatine, Marc S., Shui, Amy, Antman, Elliott M., Braunwald, Eugene
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Antithrombins - therapeutic use
Death, Sudden, Cardiac - prevention & control
Drug Therapy, Combination
ECG
Electrocardiography
Enoxaparin
Enoxaparin - therapeutic use
Female
Fibrinolytic Agents - therapeutic use
Hospital Mortality
Humans
Male
Myocardial Infarction - diagnosis
Myocardial Infarction - drug therapy
Myocardial Infarction - mortality
Secondary Prevention
ST-segment resolution
STEMI
Survival Analysis
Thrombolytic Therapy - methods
Thrombolytic Therapy - mortality
Treatment Outcome
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Zusammenfassung:Aims To determine the relationship between a strategy of enoxaparin (ENOX), early ST-segment resolution (STRes), and clinical outcomes on patients with ST-segment elevation myocardial infarction (STEMI) after fibrinolysis. Methods and results Baseline and 180 min ECGs were analysed in 3208 of the 20 479 patients in the ExTRACT-TIMI 25 trial, which randomifzed patients with STEMI to ENOX vs. unfractionated heparin (UFH) as adjunctive therapy. STRes was defined as complete (70%), partial (30–70%), or none (
ISSN:0195-668X
1522-9645
DOI:10.1093/eurheartj/ehm210