Antiamnesic effect of combined treatment with galantamine and estradiol in middle-aged ovariectomized female rats

The effect of chronic combined treatment with galantamine and 17beta-estradiol on passive avoidance retention was studied in middle-aged ovariectomized female rats (15 months) with scopolamine-induced amnesia. Combined treatment with galantamine and estradiol completely restored retrieval of memory...

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Veröffentlicht in:Bulletin of experimental biology and medicine 2006-04, Vol.141 (4), p.427-429
Hauptverfasser: Losev, N A, Fedotova, Yu O, Sapronov, N S
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creator Losev, N A
Fedotova, Yu O
Sapronov, N S
description The effect of chronic combined treatment with galantamine and 17beta-estradiol on passive avoidance retention was studied in middle-aged ovariectomized female rats (15 months) with scopolamine-induced amnesia. Combined treatment with galantamine and estradiol completely restored retrieval of memory traces in middle-aged ovariectomized female rats.
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subjects Amnesia - drug therapy
Animals
Estradiol - metabolism
Estradiol - pharmacology
Estrogens - deficiency
Female
Galantamine - pharmacology
Memory - drug effects
Muscarinic Antagonists - pharmacology
Ovariectomy
Ovary - physiology
Rats
Scopolamine - pharmacology
Time Factors
title Antiamnesic effect of combined treatment with galantamine and estradiol in middle-aged ovariectomized female rats
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