Antiamnesic effect of combined treatment with galantamine and estradiol in middle-aged ovariectomized female rats

The effect of chronic combined treatment with galantamine and 17beta-estradiol on passive avoidance retention was studied in middle-aged ovariectomized female rats (15 months) with scopolamine-induced amnesia. Combined treatment with galantamine and estradiol completely restored retrieval of memory...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2006-04, Vol.141 (4), p.427-429
Hauptverfasser:	Losev, N A, Fedotova, Yu O, Sapronov, N S
Format:	Artikel
Sprache:	eng
Schlagworte:	Amnesia - drug therapy Animals Estradiol - metabolism Estradiol - pharmacology Estrogens - deficiency Female Galantamine - pharmacology Memory - drug effects Muscarinic Antagonists - pharmacology Ovariectomy Ovary - physiology Rats Scopolamine - pharmacology Time Factors
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Beschreibung
Zusammenfassung:	The effect of chronic combined treatment with galantamine and 17beta-estradiol on passive avoidance retention was studied in middle-aged ovariectomized female rats (15 months) with scopolamine-induced amnesia. Combined treatment with galantamine and estradiol completely restored retrieval of memory traces in middle-aged ovariectomized female rats.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-006-0190-4