Smoking combined with overweight or obesity markedly elevates cardiovascular risk factors

Aims Overweight, obesity and smoking are well-established risk independent factors for cardiovascular diseases. The combination of overweight or obesity with smoking may modify other cardiovascular disease risk factors. We examined the impacts of smoking, overweight and obesity on cardiovascular risk factors: total cholesterol, high-density lipoprotein (HDL)-cholesterol, non-HDL-cholesterol, C-reactive protein and fibrinogen. Methods and results Data from 5460 adults who participated in the cross-sectional Scottish Health Survey 1998 were analysed. In multivariable analysis body mass index and smoking were the most important risk factors for cardiovascular disease. Smoking was independently associated with higher C-reactive protein and fibrinogen concentrations in both sexes, and lower HDL cholesterol and higher non-HDL cholesterol in females (P