An Efficient Base-Free N-Arylation of Imidazoles and Amines with Arylboronic Acids Using Copper-Exchanged Fluorapatite

N-Arylation of imidazoles and amines with arylboronic acids was accomplished with copper-exchanged fluorapatite (CuFAP) in methanol at room temperature. The products N-arylimidazoles and N-arylamines were isolated in good to excellent yields. A variety of arylboronic acids were converted to the corr...

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Veröffentlicht in:Journal of organic chemistry 2006-12, Vol.71 (25), p.9522-9524
Hauptverfasser: Kantam, M. Lakshmi, Venkanna, Gopaldasu T, Sridhar, Chidara, Sreedhar, Bojja, Choudary, Boyapati M
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Sprache:eng
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Zusammenfassung:N-Arylation of imidazoles and amines with arylboronic acids was accomplished with copper-exchanged fluorapatite (CuFAP) in methanol at room temperature. The products N-arylimidazoles and N-arylamines were isolated in good to excellent yields. A variety of arylboronic acids were converted to the corresponding N-arylimidazoles and N-arylamines, demonstrating the versatility of the reaction.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo0614036