Dietary supplementation with epigallocatechin gallate elevates levels of circulating adiponectin in non-obese type-2 diabetic Goto-Kakizaki rats

Epigallocatechin gallate (EGCG) reportedly enhances plasma adiponectin levels in models of insulin resistance and obesity. In this study, we found that EGCG increases plasma adiponectin levels and decreases plasma triacylglycerol levels in non-obese diabetic Goto-Kakizaki rats with insulin secretory...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2007-08, Vol.71 (8), p.2079-2082
Hauptverfasser:	Shimada, M.(Shizuoka Univ. (Japan)), Mochizuki, K, Sakurai, N, Goda, T
Format:	Artikel
Sprache:	eng
Schlagworte:	adiponectin Adiponectin - blood Animals Biological and medical sciences CATECHIN Catechin - administration & dosage Catechin - analogs & derivatives Catechin - therapeutic use CATECHINE CATEQUINA CITOQUINAS CYTOKINE CYTOKINES DIABETE DIABETES Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Type 2 - drug therapy Dietary Supplements epigallocatechin gallate (EGCG) Fundamental and applied biological sciences. Psychology Goto-Kakizaki (GK) rats insulin secretory dysfunction Lipid Metabolism - drug effects OVERWEIGHT RAT RATA RATS Rats, Inbred Strains SOBREPESO SURPOIDS TEA THE Triglycerides - blood
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Zusammenfassung:	Epigallocatechin gallate (EGCG) reportedly enhances plasma adiponectin levels in models of insulin resistance and obesity. In this study, we found that EGCG increases plasma adiponectin levels and decreases plasma triacylglycerol levels in non-obese diabetic Goto-Kakizaki rats with insulin secretory dysfunction. These results suggest that EGCG ameliorates lipid metabolic abnormality even in non-obese rats, probably by increasing adiponectin production.
ISSN:	0916-8451 1347-6947
DOI:	10.1271/bbb.70174