Discrimination of β-Ketoesters by Ruthenium(II)-Binap-Catalyzed Asymmetric Hydrogenation

Discrimination of β-Ketoesters by Ruthenium(II)-Binap-Catalyzed Asymmetric Hydrogenation

Please, after you…︁ β‐Ketoesters in mixtures underwent Noyori reduction one by one at room temperature under 4 bar of hydrogen pressure in the presence of a catalyst formed from RuII and (S)‐binap (see example). The rate of the asymmetric hydrogenation and hence the selectivity for a particular β‐ke...

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Veröffentlicht in:Angewandte Chemie (International ed.) 2007-01, Vol.46 (34), p.6537-6541
Hauptverfasser: Kramer, Rainer, Brückner, Reinhard
Format: Artikel
Sprache:eng
Schlagworte:
asymmetric catalysis
kinetics
reduction
substituent effects
β-ketoesters
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Zusammenfassung:Please, after you…︁ β‐Ketoesters in mixtures underwent Noyori reduction one by one at room temperature under 4 bar of hydrogen pressure in the presence of a catalyst formed from RuII and (S)‐binap (see example). The rate of the asymmetric hydrogenation and hence the selectivity for a particular β‐ketoester was found to depend on the Lewis basicity of the ester group. Binap=2,2′‐bis(diphenylphosphanyl)‐1,1′‐binaphthyl.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200700021