Lack of in vitro biofilm formation does not attenuate the virulence of Streptococcus gordonii in experimental endocarditis

Abstract The ability to induce experimental endocarditis of biofilm-deficient mutants of Streptococcus gordonii was studied in an isogenic background. Strains were inactivated in either comD, fruK or pbp2b genes, which are involved in biofilm formation. These strains were clearly impaired (>75% r...

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Veröffentlicht in:	FEMS immunology and medical microbiology 2006-12, Vol.48 (3), p.419-423
Hauptverfasser:	Bizzini, Alain, Beggah-Möller, Siham, Moreillon, Philippe, Entenza, José M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial Adhesion - genetics Bacterial Adhesion - physiology Bacteriology biofilm Biofilms Biofilms - growth & development Biological and medical sciences Deficient mutant Disease Models, Animal Endocarditis Endocarditis, Bacterial - microbiology Female Fundamental and applied biological sciences. Psychology Microbiology Miscellaneous Rats Streptococcal Infections - microbiology Streptococcus - genetics Streptococcus - pathogenicity Streptococcus gordonii Virulence Virulence - genetics Virulence - physiology
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Zusammenfassung:	Abstract The ability to induce experimental endocarditis of biofilm-deficient mutants of Streptococcus gordonii was studied in an isogenic background. Strains were inactivated in either comD, fruK or pbp2b genes, which are involved in biofilm formation. These strains were clearly impaired (>75% reduction) in biofilm production in vitro. However, this did not result in a decreased severity of infection in vivo.
ISSN:	0928-8244 1574-695X 2049-632X
DOI:	10.1111/j.1574-695X.2006.00168.x