Biologically Active Indole Alkaloids from Kopsia arborea

Nine new indole alkaloids, rhazinoline (1), 19(S)-methoxytubotaiwine (2), 19(R)-methoxytubotaiwine (3), kopsamidine A (4), kopsamidine B (5), kopsinidine A (6), kopsinidine B (7), paucidactine C (8), and pericine N-oxide (9), in addition to several recently reported novel indoles and 34 other known...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2007-08, Vol.70 (8), p.1302-1307
Hauptverfasser:	Lim, Kuan-Hon, Hiraku, Osamu, Komiyama, Kanki, Koyano, Takashi, Hayashi, Masahiko, Kam, Toh-Seok
Format:	Artikel
Sprache:	eng
Schlagworte:	anticarcinogenic activity Antineoplastic agents Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Apocynaceae Apocynaceae - chemistry bioactive properties Biological and medical sciences chemical structure cultured cells cytotoxicity Drug Screening Assays, Antitumor General aspects General pharmacology Humans indole alkaloids Indole Alkaloids - chemistry Indole Alkaloids - isolation & purification Indole Alkaloids - pharmacology Jurkat Cells KB Cells kopsamidine Kopsia arborea kopsinidine Malaysia Medical sciences methoxytubotaiwine Nuclear Magnetic Resonance, Biomolecular paucidactine pericine N-oxide Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Bark - chemistry Plant Stems - chemistry Plants, Medicinal - chemistry rhazinoline spectral analysis valparicine
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Zusammenfassung:	Nine new indole alkaloids, rhazinoline (1), 19(S)-methoxytubotaiwine (2), 19(R)-methoxytubotaiwine (3), kopsamidine A (4), kopsamidine B (5), kopsinidine A (6), kopsinidine B (7), paucidactine C (8), and pericine N-oxide (9), in addition to several recently reported novel indoles and 34 other known ones, were obtained from the stem-bark extract of the Malayan Kopsia arborea. The structures were determined using NMR and MS analysis. Valparicine (12) showed pronounced cytotoxic effects against KB and Jurkat cells (IC50 13.0 and 0.91 μM, respectively).
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np0702234