Leukocytosis as a predictor for progression to haemolytic uraemic syndrome in Escherichia coli O157:H7 infection

(USA) 2 O157 infection, 238 (level 3b) HUS OR 4.4 Confounding variables accounted for. with full case notes (1.6 to 12.6) However, study also included adults. included, 1998-99 Wood et al, 170 confirmed or Prospective WBC > upper Confirmed Sensitivity 88.9% Strict exclusion criteria, well validated 2001 probable E coli cohort study limit for age HUS (51.8 to 99.7) data. A normal leukocyte count will provide reliable reassurance against progression to HUS in nine out of 10 cases. 3 Similarly, leukocytosis will successfully predict progression to HUS in 70-90% of children. 3 9 Interventions like early intravenous fluid therapy have already been proven to reduce the risk for progression to HUS, while other potential measures such as the use of toxin binders remain understudied. 16 Formulation of a well defined risk assessment tool based on leukocytosis and other risk factors could help to identify high risk children and streamline the monitoring process and early use of appropriate interventions.