Autopsy Tissue Trace Elements in 8 Long-Term Parenteral Nutrition Patients Who Received the Current U.S. Food and Drug Administration Formulation
Iron, zinc, copper, manganese, chromium, and selenium levels were measured in autopsy tissues of 8 people with short bowel syndrome who received home parenteral nutrition (HPN) and the U.S. Food and Drug Administration (FDA)– approved trace element formulation for an average duration of 14 years (ra...
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Veröffentlicht in: | JPEN. Journal of parenteral and enteral nutrition 2007-09, Vol.31 (5), p.388-396 |
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Zusammenfassung: | Iron, zinc, copper, manganese, chromium, and selenium levels were measured
in autopsy tissues of 8 people with short bowel syndrome who received home
parenteral nutrition (HPN) and the U.S. Food and Drug Administration
(FDA)– approved trace element formulation for an average duration of 14
years (range, 2–21). Iron, zinc, copper, manganese and selenium were
measured by inductively coupled plasma methods; chromium, by graphite furnace
atomic absorption spectrometry. The levels in the 4 tissues studied, heart,
skeletal muscle, liver, and kidney, were compared with levels in 45 controls
who died without chronic gastrointestinal disorders. Results showed normal HPN
patient values for iron and selenium, mild elevation of zinc, and major
elevations of copper, manganese, and chromium. The implications of these
results for trace-element supplements in long-term PN adult patients are
discussed, and the need for reformulation of commercially available
multi–trace element products in the United States is stressed.
This paper examines trace elements in autopsy tissue of 8 patients receiving parenteral nutrition for an average of 14 years, and the need for reformulation of commercially available multi-trace element products in the U.S. is stressed. |
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ISSN: | 0148-6071 1941-2444 |
DOI: | 10.1177/0148607107031005388 |