Bohemamines from a Marine-Derived Streptomyces sp

Investigation of the culture extracts of a marine-derived Streptomyces sp. led to the isolation of three new bohemamine-type pyrrolizidine alkaloids, bohemamine B (1), bohemamine C (2), and 5-chlorobohemamine C (3). The structures were elucidated using NMR methods, and the relative stereochemistry w...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2006-11, Vol.69 (11), p.1626-1628
Hauptverfasser:	Bugni, Tim S, Woolery, Matthew, Kauffman, Christopher A, Jensen, Paul R, Fenical, William
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteriology Biological and medical sciences Fundamental and applied biological sciences. Psychology Marine Biology Microbiology Molecular Structure Morphology, structure, chemical composition Nuclear Magnetic Resonance, Biomolecular Pyrrolizidine Alkaloids - chemistry Pyrrolizidine Alkaloids - isolation & purification Pyrrolizidine Alkaloids - pharmacology Streptomyces Streptomyces - chemistry
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Beschreibung
Zusammenfassung:	Investigation of the culture extracts of a marine-derived Streptomyces sp. led to the isolation of three new bohemamine-type pyrrolizidine alkaloids, bohemamine B (1), bohemamine C (2), and 5-chlorobohemamine C (3). The structures were elucidated using NMR methods, and the relative stereochemistry was determined using double-pulsed-field-gradient spin echo (DPFGSE) NOE studies.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np0602721