Genetic environment of acquired bla(ACC-1) beta-lactamase gene in Enterobacteriaceae isolates

We studied the genetic organization of bla(ACC-1) in 14 isolates of Enterobacteriaceae from France, Tunisia, and Germany. In a common ancestor, ISEcp1 was likely involved in the mobilization of this gene from the Hafnia alvei chromosome to a plasmid. Other genetic events involving insertion sequence...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2006-12, Vol.50 (12), p.4177-4181
Hauptverfasser:	Doloy, A, Verdet, C, Gautier, V, Decré, D, Ronco, E, Hammami, A, Philippon, A, Arlet, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence beta-Lactamases - genetics Chromosomes, Bacterial - genetics Cross Infection - microbiology DNA Transposable Elements - genetics Enterobacteriaceae - enzymology Enterobacteriaceae - isolation & purification Enterobacteriaceae Infections - microbiology Genes, Bacterial Hafnia alvei - genetics Humans Integrons - genetics Molecular Sequence Data Open Reading Frames Plasmids - genetics
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Zusammenfassung:	We studied the genetic organization of bla(ACC-1) in 14 isolates of Enterobacteriaceae from France, Tunisia, and Germany. In a common ancestor, ISEcp1 was likely involved in the mobilization of this gene from the Hafnia alvei chromosome to a plasmid. Other genetic events involving insertion sequences (particularly IS26), transposons (particularly Tn1696), or sulI-type integrons have occurred, leading to complex genetic environments.
ISSN:	0066-4804
DOI:	10.1128/AAC.00619-06