“Click to Chelate”: Synthesis and Installation of Metal Chelates into Biomolecules in a Single Step

Click chemistry has been employed for the assembly of novel and efficient triazole-based multidentate chelating systems while simultaneously attaching them to molecules of biological interest. The “click-to-chelate” approach offers a powerful new tool for the modification of (bio)molecules with meta...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of the American Chemical Society 2006-11, Vol.128 (47), p.15096-15097
Hauptverfasser:	Mindt, Thomas L, Struthers, Harriet, Brans, Luc, Anguelov, Todor, Schweinsberg, Christian, Maes, Veronique, Tourwé, Dirk, Schibli, Roger
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine - analogs & derivatives Alkynes - chemistry Azides - chemistry Chelating Agents - chemistry Chemistry Exact sciences and technology General and physical chemistry Isotope Labeling - methods Metals - chemistry Peptides - chemistry Triazoles - chemical synthesis Triazoles - chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Click chemistry has been employed for the assembly of novel and efficient triazole-based multidentate chelating systems while simultaneously attaching them to molecules of biological interest. The “click-to-chelate” approach offers a powerful new tool for the modification of (bio)molecules with metal chelators for potential diagnostic and therapeutic applications.
ISSN:	0002-7863 1520-5126
DOI:	10.1021/ja066779f