Association of interleukin-1 gene cluster polymorphisms with ischemic stroke in a Chinese population
Background and Aims: Chronic inflammatory process plays an important role in atherothrombosis. Interleukin-1 (IL-1) is one of the key modulators of the inflammatory response and its activity is critically regulated by its receptor antagonist (IL-1Ra). A variable number tandem repeat polymorphism in...
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Veröffentlicht in: | Neurology India 2006-12, Vol.54 (4), p.366-369 |
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Sprache: | eng |
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Zusammenfassung: | Background and Aims: Chronic inflammatory process plays an important
role in atherothrombosis. Interleukin-1 (IL-1) is one of the key
modulators of the inflammatory response and its activity is critically
regulated by its receptor antagonist (IL-1Ra). A variable number tandem
repeat polymorphism in intron 2 of IL-1Ra gene and a C to T single base
polymorphism in the promoter of IL-1β gene (C-511 →T) have
been reported to affect the levels of IL-1 as well as its antagonist,
IL-1Ra. It is also reported in several studies that these polymorphisms
are associated with the susceptibility to cardio-cerebral vascular
disease. However, data are limited in China. In this article, we
studied the relationships between these polymorphisms and the risk of
ischemic stroke in China. Materials and Methods: One hundred and
twelve patients committed ischemic stroke were compared with 95
demographically matched healthy volunteers. Results: The frequencies
of the IL-1Ra 1/1 genotype and IL-1Ra allele 1 (RaFNx011 allele) in
stroke patients were significantly higher than those in healthy
volunteers [93.7% vs. 82.1%, P =0.014; 0.964 vs. 0.905, P =0.007]. No
significant differences were found in the IL-1β -511 genotype and
the allele distribution between the two groups. Conclusions: Our
results implicated that IL-1 gene polymorphism might be associated with
the susceptibility to ischemic stroke. |
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ISSN: | 0028-3886 1998-4022 |
DOI: | 10.4103/0028-3886.28107 |