Multiple malignant melanomas in association with neurofibromatosis type 1

We present a case of multiple primary malignant melanomata occurring over a six year period in a 63-year-old Caucasian man with neurofibromatosis type 1. There is doubt regarding a definite association between these two diseases despite a number of case reports and clear, potential pathological mech...

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Veröffentlicht in:Journal of plastic, reconstructive & aesthetic surgery reconstructive & aesthetic surgery, 2006-01, Vol.59 (12), p.1359-1362
Hauptverfasser: Barringer, C.B., Gorse, S.J., Rigby, H.S., Reid, C.D.
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container_issue 12
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container_title Journal of plastic, reconstructive & aesthetic surgery
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creator Barringer, C.B.
Gorse, S.J.
Rigby, H.S.
Reid, C.D.
description We present a case of multiple primary malignant melanomata occurring over a six year period in a 63-year-old Caucasian man with neurofibromatosis type 1. There is doubt regarding a definite association between these two diseases despite a number of case reports and clear, potential pathological mechanisms. This case not only strengthens support for an association but also highlights the great difficulties that arise in the management of cutaneous melanomata in patients with neurofibromatosis.
doi_str_mv 10.1016/j.bjps.2006.01.024
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source MEDLINE; Elsevier ScienceDirect Journals
subjects Biological and medical sciences
Dermatology
Humans
Male
Malignant melanoma
Medical sciences
Melanoma - pathology
Melanoma - surgery
Middle Aged
Neoplasms, Multiple Primary - pathology
Neoplasms, Multiple Primary - surgery
Neurofibromatosis
Neurofibromatosis 1 - pathology
Neurology
Skin Neoplasms - pathology
Skin Neoplasms - surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Tumors of the nervous system. Phacomatoses
Tumors of the skin and soft tissue. Premalignant lesions
Von Recklinghausen's disease
title Multiple malignant melanomas in association with neurofibromatosis type 1
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