GRASPing Unconventional Secretion

GRASP proteins associate with the Golgi apparatus and have been implicated in the stacking of Golgi cisternae, vesicle tethering, and mitotic progression, but their specific functions are unclear. In this issue, Kinseth et al. (2007) show unexpectedly that a GRASP homolog is required for an unconven...

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Veröffentlicht in:	Cell 2007-08, Vol.130 (3), p.407-409
Hauptverfasser:	Levi, Stephanie K., Glick, Benjamin S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dictyostelium - chemistry Dictyostelium - physiology Drosophila Proteins - chemistry Drosophila Proteins - metabolism Golgi Apparatus - chemistry Golgi Apparatus - physiology Golgi Matrix Proteins Membrane Proteins - chemistry Membrane Proteins - metabolism Signal Transduction - physiology
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Zusammenfassung:	GRASP proteins associate with the Golgi apparatus and have been implicated in the stacking of Golgi cisternae, vesicle tethering, and mitotic progression, but their specific functions are unclear. In this issue, Kinseth et al. (2007) show unexpectedly that a GRASP homolog is required for an unconventional secretory pathway that bypasses the usual route for Golgi-dependent membrane traffic.
ISSN:	0092-8674 1097-4172
DOI:	10.1016/j.cell.2007.07.030