Expression of Vascular Endothelial Growth Factor Receptor-2 in Merkel Cell Carcinoma

Background: The aim of this study was to examine the expression of vascular endothelial growth factor receptor-2 (VEGFR-2) in Merkel cell carcinoma (MCC) and to correlate the expression with tumour growth and the development of metastasis. Patients and Methods: The study included 21 patients treated...

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Veröffentlicht in:	Anticancer research 2007-07, Vol.27 (4C), p.2587-2589
Hauptverfasser:	KUKKO, Heli, KOLJONEN, Virve, LASSUS, Patrik, TUKIAINEN, Erkki, HAGLUND, Caj, BOHLING, Tom
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Carcinoma, Merkel Cell - metabolism Carcinoma, Merkel Cell - pathology Cell Growth Processes - physiology Humans Immunohistochemistry Medical sciences Neoplasm Metastasis Skin Neoplasms - metabolism Skin Neoplasms - pathology Tumors Vascular Endothelial Growth Factor Receptor-2 - biosynthesis
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Zusammenfassung:	Background: The aim of this study was to examine the expression of vascular endothelial growth factor receptor-2 (VEGFR-2) in Merkel cell carcinoma (MCC) and to correlate the expression with tumour growth and the development of metastasis. Patients and Methods: The study included 21 patients treated for MCC at Helsinki University Hospital, Helsinki, Finland between 1987 and 2003. The VEGFR-2 expression was studied by immunohistochemistry. The correlations between the quantitative expression of VEGFR-2 and tumour size and metastatic dissemination were analyzed statistically. Results: VEGFR-2 was expressed in 91% of the large (â¥2 cm) and 70% of the small (
ISSN:	0250-7005 1791-7530