Meningococcal disease in a kidney transplant recipient with mannose‐binding lectin deficiency

: We describe the case of a kidney transplant recipient who developed meningococcemia, without meningeal signs, 2 months after transplantation. Plasma levels of complement components C3, C4, and CH 50 were within the normal range. However, using a method to screen for the functional activity of all...

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Veröffentlicht in:Transplant infectious disease 2007-09, Vol.9 (3), p.214-218
Hauptverfasser: Manuel, O., Tarr, P.E., Venetz, J.‐P., Trendelenburg, M., Meylan, P.R., Pascual, M.
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Sprache:eng
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Zusammenfassung:: We describe the case of a kidney transplant recipient who developed meningococcemia, without meningeal signs, 2 months after transplantation. Plasma levels of complement components C3, C4, and CH 50 were within the normal range. However, using a method to screen for the functional activity of all 3 pathways of complement, no activation via the mannose‐binding lectin (MBL) pathway could be detected (0%). A subsequent quantification of MBL pathway components revealed normal levels of MASP 2 but undetectable amounts of MBL. To our knowledge, this is the first report of meningococcal disease after organ transplantation in a patient with MBL deficiency.
ISSN:1398-2273
1399-3062
DOI:10.1111/j.1399-3062.2006.00191.x