A Second-Generation Catalyst for Intermolecular Hydroacylation of Alkenes and Alkynes Using β-S-Substituted Aldehydes: The Role of a Hemilabile P-O-P Ligand

A Second-Generation Catalyst for Intermolecular Hydroacylation of Alkenes and Alkynes Using β-S-Substituted Aldehydes: The Role of a Hemilabile P-O-P Ligand

Top of the P‐O‐Ps: Stabilization of a cationic rhodium catalyst with the hemilabile P‐O‐P ligand dpephos allows efficient intermolecular hydroacylation of challenging substrates (see scheme). Structural studies have established the role of the coordination of the oxygen atom, and a catalytically com...

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Veröffentlicht in:Angewandte Chemie International Edition 2006-11, Vol.45 (45), p.7618-7622
Hauptverfasser: Moxham, Gemma L., Randell-Sly, Helen E., Brayshaw, Simon K., Woodward, Robert L., Weller, Andrew S., Willis, Michael C.
Format: Artikel
Sprache:eng
Schlagworte:
Acylation
Aldehydes - chemistry
Alkenes - chemistry
Alkynes - chemistry
Catalysis
CH activation
hemilabile ligands
homogeneous catalysis
Hot Temperature
Hydroxylation
intermolecular hydroacylation
Ligands
Molecular Structure
rhodium
Rhodium - chemistry
Sulfur - chemistry
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Zusammenfassung:Top of the P‐O‐Ps: Stabilization of a cationic rhodium catalyst with the hemilabile P‐O‐P ligand dpephos allows efficient intermolecular hydroacylation of challenging substrates (see scheme). Structural studies have established the role of the coordination of the oxygen atom, and a catalytically competent acyl–hydridorhodium intermediate was fully characterized.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200603133