Use of bi-allelic insertion/deletion polymorphisms as a positive control for fetal genotyping in maternal blood: first clinical experience

Use of bi-allelic insertion/deletion polymorphisms as a positive control for fetal genotyping in maternal blood: first clinical experience

Amplification of fetal DNA in maternal plasma is a new way for non-invasive fetal genotyping in pregnancies at risk for disorders where the presence of a paternal DNA sequence contributes to the risk status of the fetus. We describe the use of a panel of 10 bi-allelic highly polymorphic markers to a...

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Veröffentlicht in:Annals of the New York Academy of Sciences 2006-09, Vol.1075 (1), p.123-129
Hauptverfasser: Page-Christiaens, Godelieve C M L, Bossers, Bernadette, VAN DER Schoot, C Ellen, DE Haas, Masja
Format: Artikel
Sprache:eng
Schlagworte:
Alleles
DNA - blood
Female
Fetus - physiology
Gene Deletion
Genetic Markers
Genotype
Humans
Male
Maternal-Fetal Exchange
Polymorphism, Genetic
Pregnancy
Prenatal Diagnosis
Rh-Hr Blood-Group System - genetics
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Beschreibung
Zusammenfassung:Amplification of fetal DNA in maternal plasma is a new way for non-invasive fetal genotyping in pregnancies at risk for disorders where the presence of a paternal DNA sequence contributes to the risk status of the fetus. We describe the use of a panel of 10 bi-allelic highly polymorphic markers to ascertain the presence and amplification of fetal DNA in case the fetus is negative for the targeted paternal "disease" sequence.
ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1368.016