Circadian variation in restless legs syndrome

Abstract Restless legs syndrome (RLS) is a clinical disorder that currently is not characterized by a uniform pathophysiologiocal definition. The diagnosis of RLS requires circadian variation in symptoms, although no pathophysiological basis has been verified. Clinical observations and research stud...

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Veröffentlicht in:	Sleep medicine 2007-09, Vol.8 (6), p.645-650
Hauptverfasser:	Baier, P.C, Trenkwalder, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Circadian rhythm Circadian Rhythm - physiology Dopamine Dopamine - metabolism Humans Hyperalgesia - etiology Iron Iron - metabolism Neurology Prolactin - metabolism Restless legs syndrome Restless Legs Syndrome - diagnosis Restless Legs Syndrome - physiopathology RLS Sleep Medicine Sleep Stages - physiology Wakefulness - physiology
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Zusammenfassung:	Abstract Restless legs syndrome (RLS) is a clinical disorder that currently is not characterized by a uniform pathophysiologiocal definition. The diagnosis of RLS requires circadian variation in symptoms, although no pathophysiological basis has been verified. Clinical observations and research studies confirm the variation in symptoms, of both sensory and motor components, over the course of the day. This contribution reviews the current literature on circadian variation in RLS and discusses potential intrinsic and extrinsic causes.
ISSN:	1389-9457 1878-5506
DOI:	10.1016/j.sleep.2006.10.011