Characterization of an influenza A H5N2 reassortant as a candidate for live-attenuated and inactivated vaccines against highly pathogenic H5N1 viruses with pandemic potential

We generated a high-growth 7:1 reassortant (Len17/H5) that contained the hemagglutinin (HA) gene from non-pathogenic A/Duck/Potsdam/1402-6/86 (H5N2) virus and other genes from the cold-adapted ( ca) attenuated A/Leningrad/134/17/57 (H2H2) strain. Len17/H5 demonstrated an attenuated phenotype in mice...

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Veröffentlicht in:Vaccine 2006-11, Vol.24 (47), p.6859-6866
Hauptverfasser: Desheva, J.A., Lu, X.H., Rekstin, A.R., Rudenko, L.G., Swayne, D.E., Cox, N.J., Katz, J.M., Klimov, A.I.
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Sprache:eng
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