Expressions of MMP-2, MMP-9 and VEGF are Closely Linked to Growth, Invasion, Metastasis and Angiogenesis of Gastric Carcinoma

Background: Gastric carcinoma is still a major leading cause of cancer death in East Asia. Since angiogenesis is a necessary condition for invasion and metastasis, its regulation is of essential significance. Materials and Methods: Expressions of MMP-2, MMP-9 and VEGF were examined with microarray o...

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Veröffentlicht in:	Anticancer research 2006-09, Vol.26 (5A), p.3579-3583
Hauptverfasser:	HUACHUAN ZHENG, TAKAHASHI, Hiroyuki, MURAI, Yoshihiro, ZHENGGUO CUI, NOMOTO, Kazuhiro, NIWA, Hideki, TSUNEYAMA, Koichi, TAKANO, Yasuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - blood supply Adenocarcinoma - metabolism Adenocarcinoma - secondary Adult Aged Aged, 80 and over Biological and medical sciences Female Gastroenterology. Liver. Pancreas. Abdomen Humans Immunoenzyme Techniques Lymphatic Metastasis - pathology Male Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism Medical sciences Microcirculation Middle Aged Neoplasm Invasiveness - pathology Neoplasm Staging Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology PTEN Phosphohydrolase - metabolism Stomach Neoplasms - blood supply Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tissue Array Analysis Tumors Vascular Endothelial Growth Factor A - metabolism
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Zusammenfassung:	Background: Gastric carcinoma is still a major leading cause of cancer death in East Asia. Since angiogenesis is a necessary condition for invasion and metastasis, its regulation is of essential significance. Materials and Methods: Expressions of MMP-2, MMP-9 and VEGF were examined with microarray of gastric carcinoma tissue samples (n=249) by immunostaining. In addition, microvessel density (MVD) was assessed after labelling with the anti-CD34 antibody. Data were cross-compared with clinicopathological parameters of tumors, including PTEN expression. Results: Expressions of MMP-2, MMP-9 and VEGF were positively correlated with tumour size, depth of invasion, lymphatic and venous invasion, lymph node metastasis, UICC staging and MVD of gastric carcinomas (p
ISSN:	0250-7005 1791-7530