Combination of Local, Non-viral IL12 Gene Therapy and Systemic Paclitaxel Chemotherapy in a Syngeneic ID8 Mouse Model for Human Ovarian Cancer
The in vivo feasibility of the previously established ID8 and ID8-VEGF ovarian cancer models for non-viral IL-12 gene delivery by itself or in combination with paclitaxel chemotherapy, was investigated in C57BL/6 black mice. The syngeneic mouse ovarian epithelium (MOSE) cancer cell line and its more...
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Veröffentlicht in: | Anticancer research 2006-09, Vol.26 (5A), p.3223-3228 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | The in vivo feasibility of the previously established ID8 and ID8-VEGF ovarian cancer models for non-viral IL-12 gene delivery
by itself or in combination with paclitaxel chemotherapy, was investigated in C57BL/6 black mice. The syngeneic mouse ovarian
epithelium (MOSE) cancer cell line and its more aggressive variant, a VEGF-modified strain, were used to perform these experiments.
Tumor growth and survival were observed in C57/BL6 mice, inoculated with both ID8 substrains. The superiority of IL-12 gene
therapy in comparison to conventional paclitaxel chemotherapy in terms of tumor size and survival was demonstrated. |
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ISSN: | 0250-7005 1791-7530 |