Vessel Dilator and Kaliuretic Peptide Inhibit ERK 1/2 Activation in Human Prostate Cancer Cells

Background: Vessel dilator and kaliuretic peptide have anticancer effects in human prostate adenocarcinomas. Materials and Methods: Vessel dilator, kaliuretic peptide and cyclic GMP's effects on ERK 1/2 kinase were examined in human prostate adenocarcinoma cells. Results: Vessel dilator and kal...

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Veröffentlicht in:	Anticancer research 2006-09, Vol.26 (5A), p.3217-3222
Hauptverfasser:	YING SUN, EICHELBAUM, Ehrentraud J, HAI WANG, VESELY, David L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Adenocarcinoma - enzymology Atrial Natriuretic Factor - pharmacology Biological and medical sciences Cyclic GMP - pharmacology Enzyme Activation - drug effects Humans Immunoblotting Male Medical sciences Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Natriuresis Nephrology. Urinary tract diseases Peptide Fragments - pharmacology Phosphorylation - drug effects Prostatic Neoplasms - drug therapy Prostatic Neoplasms - enzymology Protein Precursors - pharmacology Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors Tumor Cells, Cultured Tumors Tumors of the urinary system Urinary tract. Prostate gland
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Zusammenfassung:	Background: Vessel dilator and kaliuretic peptide have anticancer effects in human prostate adenocarcinomas. Materials and Methods: Vessel dilator, kaliuretic peptide and cyclic GMP's effects on ERK 1/2 kinase were examined in human prostate adenocarcinoma cells. Results: Vessel dilator and kaliuretic peptide decreased the activation of ERK 1/2 over a concentration range of 0.01 Î¼M to 1 Î¼M. Vessel dilator and kaliuretic peptide (each 1 Î¼M) inhibited the phosphorylation of ERK 1/2 kinase 96% (p
ISSN:	0250-7005 1791-7530