Effect of Pregnancy on the Pharmacokinetics of Paclitaxel: A Case Report
Breast cancer during pregnancy is increasingly common as women delay childbearing until later in life. Safe administration of adjuvant chemotherapy during pregnancy has been reported. Physiologic and metabolic changes during pregnancy could alter the pharmacokinetics of these agents. This is a pilot...
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| Veröffentlicht in: | Clinical breast cancer 2006-10, Vol.7 (4), p.342-344 |
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| container_end_page | 344 |
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| container_issue | 4 |
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| container_title | Clinical breast cancer |
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| creator | Lycette, Jennifer L. Dul, Carrie L. Munar, Myrna Belle, Donna Chui, Stephen Y. Koop, Dennis R. Nichols, Craig R. |
| description | Breast cancer during pregnancy is increasingly common as women delay childbearing until later in life. Safe administration of adjuvant chemotherapy during pregnancy has been reported. Physiologic and metabolic changes during pregnancy could alter the pharmacokinetics of these agents. This is a pilot study to prospectively study the pharmacokinetics of chemotherapeutic agents during pregnancy. Herein, we report the initial results with paclitaxel in the first patient. |
| doi_str_mv | 10.3816/CBC.2006.n.049 |
| format | Article |
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Safe administration of adjuvant chemotherapy during pregnancy has been reported. Physiologic and metabolic changes during pregnancy could alter the pharmacokinetics of these agents. This is a pilot study to prospectively study the pharmacokinetics of chemotherapeutic agents during pregnancy. Herein, we report the initial results with paclitaxel in the first patient.</description><identifier>ISSN: 1526-8209</identifier><identifier>EISSN: 1938-0666</identifier><identifier>DOI: 10.3816/CBC.2006.n.049</identifier><identifier>PMID: 17092404</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Antineoplastic Agents - therapeutic use ; Antineoplastic Combined Chemotherapy Protocols ; Area Under Curve ; Breast Neoplasms - drug therapy ; Carcinoma, Ductal - drug therapy ; Chemotherapy ; Dose-dense therapy ; Female ; Half-Life ; Humans ; Live Birth ; Paclitaxel - pharmacokinetics ; Paclitaxel - therapeutic use ; Pregnancy ; Pregnancy Complications, Neoplastic - drug therapy ; Taxanes ; Treatment Outcome ; Twins</subject><ispartof>Clinical breast cancer, 2006-10, Vol.7 (4), p.342-344</ispartof><rights>2006 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-bc6346ed4757b5666cb1314b848ec8cee1436c172360cf6c4e555b54a9872fbb3</citedby><cites>FETCH-LOGICAL-c342t-bc6346ed4757b5666cb1314b848ec8cee1436c172360cf6c4e555b54a9872fbb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.3816/CBC.2006.n.049$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17092404$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lycette, Jennifer L.</creatorcontrib><creatorcontrib>Dul, Carrie L.</creatorcontrib><creatorcontrib>Munar, Myrna</creatorcontrib><creatorcontrib>Belle, Donna</creatorcontrib><creatorcontrib>Chui, Stephen Y.</creatorcontrib><creatorcontrib>Koop, Dennis R.</creatorcontrib><creatorcontrib>Nichols, Craig R.</creatorcontrib><title>Effect of Pregnancy on the Pharmacokinetics of Paclitaxel: A Case Report</title><title>Clinical breast cancer</title><addtitle>Clin Breast Cancer</addtitle><description>Breast cancer during pregnancy is increasingly common as women delay childbearing until later in life. Safe administration of adjuvant chemotherapy during pregnancy has been reported. Physiologic and metabolic changes during pregnancy could alter the pharmacokinetics of these agents. This is a pilot study to prospectively study the pharmacokinetics of chemotherapeutic agents during pregnancy. 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| fulltext | fulltext |
| identifier | ISSN: 1526-8209 |
| ispartof | Clinical breast cancer, 2006-10, Vol.7 (4), p.342-344 |
| issn | 1526-8209 1938-0666 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Antineoplastic Agents - therapeutic use Antineoplastic Combined Chemotherapy Protocols Area Under Curve Breast Neoplasms - drug therapy Carcinoma, Ductal - drug therapy Chemotherapy Dose-dense therapy Female Half-Life Humans Live Birth Paclitaxel - pharmacokinetics Paclitaxel - therapeutic use Pregnancy Pregnancy Complications, Neoplastic - drug therapy Taxanes Treatment Outcome Twins |
| title | Effect of Pregnancy on the Pharmacokinetics of Paclitaxel: A Case Report |
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