Effect of Pregnancy on the Pharmacokinetics of Paclitaxel: A Case Report

Breast cancer during pregnancy is increasingly common as women delay childbearing until later in life. Safe administration of adjuvant chemotherapy during pregnancy has been reported. Physiologic and metabolic changes during pregnancy could alter the pharmacokinetics of these agents. This is a pilot...

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Veröffentlicht in:	Clinical breast cancer 2006-10, Vol.7 (4), p.342-344
Hauptverfasser:	Lycette, Jennifer L., Dul, Carrie L., Munar, Myrna, Belle, Donna, Chui, Stephen Y., Koop, Dennis R., Nichols, Craig R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antineoplastic Agents - therapeutic use Antineoplastic Combined Chemotherapy Protocols Area Under Curve Breast Neoplasms - drug therapy Carcinoma, Ductal - drug therapy Chemotherapy Dose-dense therapy Female Half-Life Humans Live Birth Paclitaxel - pharmacokinetics Paclitaxel - therapeutic use Pregnancy Pregnancy Complications, Neoplastic - drug therapy Taxanes Treatment Outcome Twins
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Zusammenfassung:	Breast cancer during pregnancy is increasingly common as women delay childbearing until later in life. Safe administration of adjuvant chemotherapy during pregnancy has been reported. Physiologic and metabolic changes during pregnancy could alter the pharmacokinetics of these agents. This is a pilot study to prospectively study the pharmacokinetics of chemotherapeutic agents during pregnancy. Herein, we report the initial results with paclitaxel in the first patient.
ISSN:	1526-8209 1938-0666
DOI:	10.3816/CBC.2006.n.049