Factors Associated with Variability in Retinal Nerve Fiber Layer Thickness Measurements Obtained by Optical Coherence Tomography

Objective To identify factors associated with variability in retinal nerve fiber layer (RNFL) thickness measurements obtained by optical coherence tomography (OCT). Design Retrospective observational case series. Participants One hundred fifty consecutive patients with known or suspected glaucomatou...

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Veröffentlicht in:Ophthalmology (Rochester, Minn.) Minn.), 2007-08, Vol.114 (8), p.1505-1512
Hauptverfasser: Wu, Ziqiang, MD, Vazeen, Matti, MD, Varma, Rohit, MD, MPH, Chopra, Vikas, MD, Walsh, Alexander C., MD, LaBree, Laurie D., MS, Sadda, Srinivas R., MD
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Sprache:eng
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Zusammenfassung:Objective To identify factors associated with variability in retinal nerve fiber layer (RNFL) thickness measurements obtained by optical coherence tomography (OCT). Design Retrospective observational case series. Participants One hundred fifty consecutive patients with known or suspected glaucomatous optic nerve damage undergoing OCT imaging for RNFL thickness measurement. Methods One eye with known or suspected glaucoma from each patient was scanned twice within the same visit using the Stratus OCT’s fast nerve fiber layer thickness acquisition protocol. For each scan, the average RNFL thickness, signal strength (a measure of the amount of light reflecting back from the retina), and analysis confidence (AC, a measure of the quality of the data as reported by the OCT software) were recorded. Retinal nerve fiber layer thickness measurements of the initial and repeat scans for each case were compared, and the difference in thickness measurements was correlated with difference in signal strength, AC (either low or normal), and the average RNFL thickness. Main Outcome Measure Difference in RNFL thickness. Results The mean difference in RNFL thickness between the initial and repeat scans was 10 microns (12.5%; range, 0.04–86.15 microns). Difference in signal strength between initial and repeat scans positively correlated with the difference in RNFL thickness (Spearman correlation coefficient = 0.44; P
ISSN:0161-6420
1549-4713
DOI:10.1016/j.ophtha.2006.10.061